艾曲泊帕联合环孢素治疗原发性血小板减少症的临床疗效分析  

Analysis of Clinical Effect of Eltrombopag Combined with Cyclosporine in the Treatment of Primary Thrombocytopenia

作　　者：袁文志 YUAN Wenzhi(Department of Hematology,Huai'an Fifth People's Hospital,Huai'an,Jiangsu,223300,China)

机构地区：[1]淮安市第五人民医院血液科,江苏淮安223300

出　　处：《中外医疗》2024年第34期82-85,共4页China & Foreign Medical Treatment

摘　　要：目的分析原发性血小板减少症患者采取艾曲泊帕+环孢素治疗的临床效果。方法随机选取2018年3月—2021年3月淮安市第五人民医院收治的60例原发性血小板减少症患者为研究对象,依据不同治疗方法分为对照组、观察组,每组30例。对照组采用环孢素治疗,观察组联合艾曲泊帕治疗,比较两组患者治疗前、后血小板计数,不良反应发生率,治疗有效率及生活质量评分。结果观察组治疗有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(χ^(2)=4.706;P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗前及治疗3个月,两组患者血小板计数比较,差异均无统计学意义(P均>0.05);治疗后6个月,观察组血小板计数高于对照组,差异有统计学意义(P<0.05)。治疗6个月后,观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论血小板减少症患者采取艾曲泊帕+环孢素治疗,可提升治疗总有效率,降低不良反应发生率,改善血小板水平,提高生活质量。Objective To analyze the clinical effect of treating patients with primary thrombocytopenia with eltrom-bopag and cyclosporine.Methods 60 patients with essential thrombocytopenia treated in the huai'an Fifth People's Hospital from March 2018 to March 2021 were randomly selected as the study objects,and were divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with cyclosporine,and the observation group combined with eltrombopag treatment.Platelet counts,inci-dence of adverse reactions,treatment effectiveness and quality of life scores were compared between the two groups before and after treatment.Results The effective rate of the observation group was 96.67%(29/30),which was higher than that of the control group 73.33%(22/30),the difference was statistically significant(χ^(2)=4.706;P<0.05).The inci-dence of adverse reactions in observation group was lower than that in control group,and the difference was statisti-cally significant(P<0.05).There was no significant difference in platelet count between two groups before treatment and 3 months after treatment(both P>0.05).At 6 months after treatment,the platelet count in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).At 6 months after treatmen,the life quality score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The total effective rate and the incidence of adverse reactions in pa-tients with thrombocytopenia can be increased by the treatment of Altropopa+cyclosporine,and improve platelet lev-els,improve quality of life.

关 键 词：艾曲泊帕 环孢素 原发性血小板减少症 

分 类 号：R558.2[医药卫生—血液循环系统疾病]