重症肾衰竭患者的连续性血液净化与间歇性血液透析治疗效果对比  

Comparison of therapeutic effects of continuous blood purification and intermittent hemodialysis in patients with severe renal failure

作　　者：徐飞[1] XU Fei(Intensive Care Unit,Lianshui County People's Hospital,Huai'an 223400,China)

机构地区：[1]涟水县人民医院重症医学科,223400

出　　处：《中国实用医药》2024年第23期54-57,共4页China Practical Medicine

摘　　要：目的分析重症肾衰竭患者采取间歇性血液透析(IHD)与连续性血液净化(CBP)治疗的效果。方法100例重症肾衰竭患者,随机分为观察组和对照组,每组50例。观察组行CBP治疗,对照组采用IHD治疗。比较两组患者炎症因子[C反应蛋白(CRP)、白介素6(IL-6)]水平、急性生理学及慢性健康状况(APACHEⅡ)评分、血尿素氮(BUN)、血肌酐(Scr)、平均动脉压(MAP)、心率(HR)、并发症发生情况、生活质量。结果治疗后,观察组患者CRP(10.21±1.14)mg/L、IL-6(28.44±3.10)pg/ml均低于对照组的(13.42±2.09)mg/L、(32.52±4.20)pg/ml,差异显著(P<0.05)。治疗后,观察组APACHEⅡ评分(14.84±2.65)分、BUN(20.33±4.03)mmol/L、Scr(277.47±41.20)μmol/L、MAP(87.26±6.37)mm Hg(1mm Hg=0.133kPa)、HR(115.02±10.76)次/min均优于对照组的(18.69±2.90)分、(28.76±4.30)mmol/L、(378.94±45.64)μmol/L、(70.34±5.92)mm Hg、(130.45±11.87)次/min,差异显著(P<0.05)。观察组并发症发生率6.00%低于对照组的20.00%,差异显著(P<0.05)。治疗后,观察组患者日常生活评分(92.73±1.01)分、疲乏评分(92.02±1.31)分、睡眠评分(93.11±1.03)分、精神评分(90.26±1.57)分、食欲评分(92.04±1.33)分均高于对照组的(86.42±2.38)、(84.24±2.08)、(88.92±2.19)、(85.02±2.40)、(86.41±2.58)分,差异显著(P<0.05)。结论对于重症肾衰竭患者来讲,相比于IHD,CBP治疗效果更理想,值得应用。Objective To analyze the effects of intermittent hemodialysis(IHD)and continuous blood purification(CBP)in patients with severe renal failure.Methods 100 patients with severe renal failure were randomly divided into an observation group and a control group,with 50 cases in each group.The observation group was treated with CBP,and the control group was treated with IHD.Comparison was made on levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)],acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores,blood urea nitrogen(BUN),serum creatinine(Scr),mean arterial pressure(MAP),heart rate(HR),complications and quality of life between the two groups.Results After treatment,the observation group had CRP of(10.21±1.14)mg/L and IL-6 of(28.44±3.10)pg/ml,which were lower than(13.42±2.09)mg/L and(32.52±4.20)pg/ml in the control group,and the difference was significant(P<0.05).After treatment,the observation group had APACHEⅡscore of(14.84±2.65)points,BUN of(20.33±4.03)mmol/L,Scr of(277.47±41.20)μmol/L,MAP of(87.26±6.37)mm Hg(1 mm Hg=0.133 kPa),and HR of(115.02±10.76)beats/min,which were significantly higher than(18.69±2.90)min,(28.76±4.30)mmol/L,(378.94±45.64)μmol/L,(70.34±5.92)mm Hg,and(130.45±11.87)beats/min in the control group,and the difference was significant(P<0.05).The incidence of complications of 6.00%in the observation group was lower than 20.00%in the control group,and the difference was significant(P<0.05).After treatment,the daily life score of the observation group was(92.73±1.01)points,the fatigue score was(92.02±1.31)points,the sleep score was(93.11±1.03)points,the mental score was(90.26±1.57)points,and the appetite score was(92.04±1.33)points,which were higher than(86.42±2.38),(84.24±2.08),(88.92±2.19),(85.02±2.40),and(86.41±2.58)points in the control group,and the difference was significant(P<0.05).Conclusion Compared with IHD,CBP is more effective in the treatment of patients with severe renal failure,and it is worth applying.

关 键 词：间歇性血液透析 重症肾衰竭 连续性血液净化 生活质量 并发症 肾功能 

分 类 号：R692.5[医药卫生—泌尿科学]