痛泻要方联合鳖甲灸及循经摩腹治疗腹泻型肠易激综合征的随机对照试验  

Randomized controlled trial of Tongxie Yaofang combined with turtle-shellpartitioned moxibustion and meridian massage in the treatment of irritable bowel syndrome with diarrhea

作　　者：姚婕妤 杨芳[1] 冯娟[1] YAO Jieyu;YANG Fang;FENG Juan(Department of Gastroenterology,Nantong Hospital of Traditional Chinese Medicine,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通市中医院消化内科,江苏南通226001

出　　处：《药学前沿》2024年第12期679-685,共7页China Pharmacist

基　　金：南通市基础科学研究和社会民生科技计划项目(指导性)(MSZ2022005)。

摘　　要：目的分析痛泻要方(TXYF)联合鳖甲灸(TSPM)及偱经摩腹(MM)治疗肝郁脾虚证腹泻型肠易激综合征(IBS-D)的疗效。方法招募2022年6月至2024年6月南通市中医院消化内科诊治的肝郁脾虚证IBS-D患者为研究对象,随机均等分为TXYF组和联合组。本研究主要疗效指标为治疗总有效率,次要疗效指标为中医证候(TCM-SS)、生活质量量表(IBS-QOL)、病情严重程度量表(IBS-SSS)评分、汉密顿焦虑量表(HAMA)和汉密顿抑郁量表(HAMD)评分、血清白细胞介素-10(IL-10)和白细胞介素-12(IL-12)含量。结果研究共纳入96例患者,TXYF组和联合组各48例患者。治疗2周后,联合组治疗总有效率显著高于TXYF组(P<0.05)。此外,联合组TCM-SS总分、IBS-SSS评分、HAMA评分、HAMD评分和血清IL-12含量显著低于TXYF组,而IBS-QOL评分和血清IL-10含量显著高于TXYF组(P<0.05)。结论TXYF联合TSPM及MM可通过调节炎症水平来改善IBS-D患者的临床疗效。Objective To investigate the efficacy of Tongxie Yaofang(TXYF)combined with turtle-shell-partitioned moxibustion(TSPM)and meridian massage(MM)in Diarrhea-predominant irritable bowel syndrome with diarrhea(IBS-D)patients with liver depression and spleen deficiency.Methods Patients with IBS-D characterized by liver stagnation and spleen deficiency from June 2022 to June 2024 at the Department of Gastroenterology,Nantong Hospital of Traditional Chinese Medicine were recruited,and randomly equally divided into the TXYF group and the combined therapy group.The primary outcome indicator was the overall effectiveness rate.Secondary outcome indicators included the traditional Chinese medicine syndrome score(TCM-SS),scores of the irritable bowel syndrome quality of life scale(IBS-QOL),the irritable bowel syndrome symptom severity scale(IBS-SSS),the Hamilton anxiety scale(HAMA),the Hamilton depression scale(HAMD),and serum levels of interleukin-10(IL-10)and interleukin-12(IL-12).Results A total of ninety-six patients were included,with 48 patients in both the TXYF group and the combined therapy group.After two weeks of treatment,the overall effectiveness rate in the combined therapy group was significantly higher than that in the TXYF group(P<0.05).Furthermore,the TCM-SS total score,IBS-SSS score,HAMA score,HAMD score,and serum IL-12 levels of the combined therapy group were significantly lower than those of the TXYF group,while the IBS-QOL score and serum IL-10 levels were significantly higher than those of the TXYF group(P<0.05).Conclusion TXYF combined with TSPM and MM can improve the clinical treatment effects of IBS-D by regulating the levels of inflammation.

关 键 词：痛泻要方 鳖甲灸 循经摩腹 肝郁脾虚 腹泻型肠易激综合征 

分 类 号：R244[医药卫生—针灸推拿学]