血清PCT、CRP联合IL-6对胃癌切除术后肠梗阻的预测价值  

The predictive value of serum PCT,CRP combined with IL-6 for intestinal obstruction after gastric cancer resection

作　　者：陈中琦 何秀梅[1] 黄炜[1] 傅艳芳 CHEN Zhongqi;HE Xiumei;HUANG Wei(The First People's Hospital of Jiande,Zhejiang 311600,China)

机构地区：[1]浙江省建德市第一人民医院,建德311600

出　　处：《浙江创伤外科》2024年第12期2201-2204,共4页Zhejiang Journal of Traumatic Surgery

摘　　要：目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)联合白细胞介素-6(IL-6)对胃癌切除术后肠梗阻的预测价值。方法选取本院2021年6月至2024年6月接受胃癌切除术治疗的80例患者进行研究,将术后发生肠梗阻6例患者作为研究组,未发生肠梗阻的74例患者作为对照组。比较研究组和对照组、研究组不同预后患者血清CRP、PCT、IL-6水平,并采用受试者工作特征曲线(ROC)评价血清PCT、CRP联合IL-6对胃癌切除术后肠梗阻的预测价值。结果研究组患者血清CRP、PCT、IL-6水平均明显高于对照组(P<0.05);预后不良组肠梗阻患者的CRP、PCT、IL-6水平水平高于预后良好组(P<0.05);采用ROC曲线分析结果显示,血清CRP、PCT、IL-6及联合检测的曲线下面积(AUC)分别为0.728、0.654、0.750、0.869,敏感度分别为0.630、0.513、0.524、0.973,特异度分别为0.723、0.752、0.766、0.814,联合检测的AUC最大且敏感度最高(P<0.05)。结论血清PCT、CRP联合IL-6的检测能够显著提高胃癌切除术后肠梗阻的早期预测准确性,三者联合应用能够更全面反映术后炎症及病情程度,为临床早期干预提供有力依据,从而改善患者预后。Objective To investigate the predictive value of serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)in intestinal obstruction after gastrectomy.Methods A total of 80 patients who received gastrectomy in our hospital from June 2021 to June 2024 were selected in this study,6 patients with postoperative intestinal obstruction were selected as the study group,and 74 patients without postoperative intestinal obstruction were selected as the control group.The serum levels of CRP,PCT and IL-6 were compared between the two groups,the prognosis and the predictive value of serum PCT and CRP combined with IL-6 in the study group was evaluated by receiver operating characteristic curve(ROC).Results The serum levels of CRP,PCT and IL-6 in study group were significantly higher than those in control group(P<0.05).The levels of CRP,PCT and IL-6 in patients with postoperative intestinal obstruction in poor prognosis group were higher than those in good prognosis group(P<0.05).ROC curve analysis showed that the area under curve(AUC)of serum CRP,PCT,IL-6 and combined detection were 0.728,0.654,0.750 and 0.869,and the sensitivity was 0.630,0.513,0.524 and 0.973,respectively.The specificities were 0.723,0.752,0.766 and 0.814,and the area under the ROC curve of combined detection was the largest and the sensitivity was the highest(P<0.05).Conclusion The detection of serum PCT and CRP combined with IL-6 can significantly improve the early prediction accuracy of intestinal obstruction after gastrectomy,and can more comprehensively reflect the postoperative inflammation,providing a strong basis for early clinical intervention,so as to improve the prognosis of patients.

关 键 词：胃癌切除术 肠梗阻 降钙素原 C反应蛋白 白细胞介素-6 

分 类 号：R656.6[医药卫生—外科学]