西安地区人群红细胞血型抗原免疫原性的研究  

Immunogenicity of red blood cell blood group antigens in the population of Xi′an

作　　者：张良子 左琴琴[1] 徐华[1] 张泳[1] 吴大洲[1] 田雪 褚晓月 ZHANG Liangzi;ZUO Qinqin;XU Hua;ZHANG Yong;WU Dazhou;TIAN Xue;CHU Xiaoyue(Blood Center of Shaanxi Province,Xi′an 710061,China)

机构地区：[1]陕西省血液中心,陕西西安710061

出　　处：《中国输血杂志》2024年第12期1394-1398,共5页Chinese Journal of Blood Transfusion

基　　金：陕西省科技计划项目(2024SF-YBXM-150);中国输血协会威高科研基金资助项目(CSBT-WG-2023-02);西安市科技计划项目(22YXYJ0068、21YXYJ0083)。

摘　　要：目的评估西安地区人群红细胞血型抗原的免疫原性。方法分析2019年1月—2024年5月陕西省血液中心无偿献血者血型抗原与临床送检病例检出意外抗体数据,采用Giblett血型抗原免疫原性计算公式,根据意外抗体频率和抗原阴性的患者接受抗原阳性红细胞的概率得到血型抗原相对K抗原免疫原性,乘以K抗原免疫原性0.095计算每个血型抗原的免疫原性。结果共纳入30921人红细胞血型抗原,511例意外抗体鉴定结果,红细胞血型抗原免疫原性的排序为:整体人群Wra>E>Dib>Fya>K>C>e>c>Dia>Jka>M>Lea>Jkb>Leb>Fyb>S,男性Dib>Wra>E>K>Fya>C>e>c>M>Dia>Jka>Fyb>Lea>Leb>Jkb>S。结论根据中国西安地区人群免疫原性由强到弱排序,为红细胞抗原拓展匹配抗原选择提供理论支持,为实现红细胞精准输注,提高输注疗效和安全性提供技术支撑。Objective To evaluate the immunogenicity of red blood cell blood group antigens in the population of Xi′an.Methods Data on blood group antigens of voluntary blood donors from the Shaanxi Province Blood Center and unexpected an-tibody detection results from clinically submitted cases between January 2019 and May 2024 were analyzed.The Giblett blood group antigen immunogenicity calculation formula was used to calculate the immunogenicity of blood group antigens based on the frequency of unexpected antibodies and the probability of antigen-negative patients receiving antigen-positive red blood cells.The relative immunogenicity of each blood group antigen was obtained by multiplying the immunogenicity of the K anti-gen(0.095).Results A total of 30921 individuals were included for red blood cell blood group antigen analysis,with 511 cases of unexpected antibody identification.The ranking of red blood cell blood group antigen immunogenicity for the overall population was:Wra>E>Dib>Fya>K>C>e>c>Dia>Jka>M>Lea>Jkb>Leb>Fyb>S,while for males,it was:Dib>Wra>E>K>Fya>C>e>c>M>Dia>Jka>Fyb>Lea>Leb>Jkb>S.Conclusion Based on the immunogenicity ranking from strong to weak of red blood cell antigens in the population of Xi′an,this study provides theoretical support for the expansion and matching of anti-gens,and technical support for achieving precise red blood cell transfusions to improve transfusion efficacy and safety.

关 键 词：免疫原性 同种异体免疫 血型 输血医学 

分 类 号：R457.11[医药卫生—治疗学] R331.141[医药卫生—临床医学]