少白细胞血小板单采相关淋巴细胞减少——从关切、淡化到再度关切  

Lymphocytopenia associated with leucocyte-reduced platelet apheresis:form concern,wane to concern again

作　　者：郭永建[1,2] 王丽梅 曾嘉[1] GUO Yongjian;WANG Limei;ZENG Jia(Fujian Provincial Blood Centre,Fuzhou 350004,China;Sub-Committee of Blood Standards,National Committee of Health Standard)

机构地区：[1]福建省血液中心,福建福州350004 [2]国家卫生健康标准委员会血液标准专业委员会

出　　处：《中国输血杂志》2024年第12期1450-1455,共6页Chinese Journal of Blood Transfusion

摘　　要：在单采血小板技术应用初期,曾关切高频次血小板单采可能导致献血者体内淋巴细胞损失过度的潜在风险。随着单采血小板技术的进步和采集纯度与效率的提高,对这一问题的关切逐步被淡化。近年来,随着单采白细胞减少血小板技术的广泛应用,该问题再度成为国际输血界的关切和研究热点。本文在对这一关切简要回顾的基础上,重点介绍近年的研究进展,并提出了相关防控和研究建议。In the early stage of the application of platelet apheresis technology,there was a concern that high-frequency platelet apheresis might lead to the risk of lymphocyte depletion in blood donors.With the advances in platelet apheresis technology and improvements in collection purity and efficiency,this concern was waning.In recent years,with the wide application of leucocyte-reduced platelet apheresis,this issue has once again become a concern and research hotspot in the international blood transfusion research field.We briefly review this concern and focus on the research progress in recent years and put forward some suggestions to reduce this potential risk and of further research.

关 键 词：淋巴细胞减少 单采血小板 献血不良反应 

分 类 号：R457.14[医药卫生—治疗学] R331.143[医药卫生—临床医学] R331.144