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作 者:王佳[1,2] 张子雄 李凯旋 潘炀烜 魏强林 刘义保[1,2,3] WANG Jia;ZHANG Zixiong;LI Kaixuan;PAN Yangxuan;WEI Qianglin;LIU Yibao(Engineering Research Center of Nuclear Technology Application,Ministry of Education(East China University of Technology),Nanchang 330013,China;School of Nuclear Science and Engineering,East China University of Technology,Nanchang 330013,China;Engineering Technology Research Center of Nuclear Radiation Detection and Application,Nanchang 330013,China)
机构地区:[1]东华理工大学核技术应用教育部工程研究中心,南昌330013 [2]东华理工大学核科学与工程学院,南昌330013 [3]江西省核辐射探测及应用工程技术研究中心,南昌330013
出 处:《核技术》2024年第12期7-15,共9页Nuclear Techniques
基 金:教育部核技术应用教育部工程研究中心开放基金项目(No.HJSJYB2021-9);国家自然基金项目(No.11965001);东华理工大学博士启动基金项目(No.DHBK2021005)资助。
摘 要:硼中子俘获治疗(Boron Neutron Capture Therapy,BNCT)是一种在细胞尺度内具有强靶向性与高传能线密度的二元放射疗法,具有治疗周期短、对周围健康组织损伤小等优势,是一种具有广阔前景的癌症治疗方法。在BNCT装置中,束流整形(Beam Shaping Assembly,BSA)组件的作用是将中子源产生的快中子束慢化至超热中子能区(0.5 eV<E<10 keV),并保证中子方向性。本文使用蒙特卡罗模拟程序GEANT4以及FLUKA模拟^(9)Be(d,n)^(10)B反应中子源产生及后续中子慢化。采用1.45 MeV、30 mA的氘束轰击9μm的薄铍靶,并使用由该反应产生的中子作为源项,对束流整形体(Beam Shaping Assembly,BSA)进行方案设计。结果表明:采用20 cm厚的BiF_(3)和30 cm厚的MgF_(2)组合慢化层,30 cm厚的Pb反射层,9cm厚的MgF_(2)补充慢化层,以及0.2 mm厚的Cd热中子吸收层,以确保出口处的γ成分、快中子成分、Φ_(epi)/Φ_(th)以及Φ_(epi)/Φ_(fast)符合国际原子能机构(International Atomic Energy Agency,IAEA)所推荐的建议值。本研究得出了低能氘束与薄铍靶的中子谱及BSA具体设计方案,为D-Be中子源中子的慢化整形提供了数据参考,为D-Be源进一步优化研究提供支持。[Background]Boron Neutron Capture Therapy(BNCT)is a binary radiation therapy with strong targeting and high energy transfer line density at the cellular scale.It has the advantages of short treatment cycle and minimal damage to surrounding healthy tissues,making it a promising cancer treatment method.[Purpose]This study aims to design beam shaping assembly(BSA)to make the neutron beam of D-Be neutron source suitable for BNCT and ensure neutron directionality.[Methods]The Monte Carlo simulation programs GEANT4 and FLUKA were employed to simulate the generation of ^(9)Be(d,n)^(10)B reaction neutron sources and subsequent neutron moderation.Then,a scheme design for BSA was carried out using a 1.45 MeV,30 mA deuterium beam to bombard a 9μm thin beryllium target,and set a basis BSA model with a cylindrical structure as a whole.[Results]The simulation results show that using a 20 cm thick BiF_(3) and 30 cm thick MgF_(2) combined slowing layer,a 30 cm thick Pb reflector layer,a 9 cm thick MgF_(2) supplementary slowing layer,and a 0.2 mm thick Cd thermal neutron absorption layer,the outlet is ensured toγand fast neutron composition,Φ_(epi)/Φ_(th),Φ_(epi)/Φ_(fast) meets the recommended values of the IAEA(International Atomic Energy Agency).[Conclusions]This study obtained the neutron spectra and BSA specific design scheme of low-energy deuterium beams and thin beryllium targets,providing data reference for the slowing shaping of neutrons in D-Be neutron sources and supporting subsequent research on D-Be sources.
关 键 词:硼中子俘获治疗 氘铍中子源 束流整形组件 中子慢化
分 类 号:TL99[核科学技术—核技术及应用]
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