厄贝沙坦及其关键中间体的合成方法述评  

Review on Synthesis of Irbesartan and Its Key Intermediates

作　　者：薛菲 XUE Fei(Xi'an Medical College,Xi'an 710309,China)

机构地区：[1]西安医学高等专科学校,陕西西安710309

出　　处：《精细化工中间体》2024年第6期7-12,共6页Fine Chemical Intermediates

摘　　要：综述了厄贝沙坦的合成工艺,使用1-氨基环戊基甲酰胺法先合成氮杂螺环、再与4'-溴甲基-2-氰基联苯对接合成厄贝沙坦的工艺仍然是使用最普遍的路线。甘氨酸甲酯盐酸盐工艺、戊酰胺工艺以及对溴苄胺工艺属于后合成氮杂螺环工艺,尚不成熟,有待进一步研究。The synthesis of Irbesartan was documented.The method of using the 1-aminocyclopentyl formamide to preparation of Irbesartan is stll the most common process.The approach involves synthesizing azospira,followed by reacting it with 4'-bromomethyl-2-cyanobiphenyl to produce Irbesartan.The glycine methyl ester hydrochloride process,valeramide process and p-bromobenzylamine process belong to the post-synthesis of azospira.These methods are still in developmental stages and require further research.

关 键 词：厄贝沙坦 氮杂螺环 1-氨基环戊基甲酰胺 

分 类 号：TQ460.31[化学工程—制药化工]