中医药通过调节肠道菌群防治心力衰竭的研究进展  

Research Progress on Prevention and Treatment of Heart Failure by Regulating Intestinal Flora with Traditional Chinese Medicine

作　　者：李豫 卢超[1] 王运华 谭熊瑶 张继红[1] Li Yu;Lu Chao;Wang Yunhua;Tan Xiongyao;Zhang Jihong(Department of Integrated Traditional Chinese and Western Medicine in Cardiovascular,The Second People's Hospital Affiliated to China Three Gorges University,Yichang 443000,China;Department of Cardiology,Yichang Hospital of Traditional Chinese Medicine,Yichang 443003,China)

机构地区：[1]三峡大学附属第二人民医院中西医结合心血管科,湖北宜昌443000 [2]三峡大学附属中医医院心病科,湖北宜昌443003

出　　处：《巴楚医学》2024年第4期124-128,共5页Bachu Medical Journal

基　　金：湖北省教育厅科学技术研究计划优秀中青年人才项目(No:Z202284)。

摘　　要：肠道菌群失调存在于心力衰竭(HF)的患者中,HF患者肠壁通透性增加,肠道微生物群以及代谢物紊乱,继而发生炎症反应促进HF进一步加重。中医药可以通过调节肠道细菌代谢产物氧化三甲胺(TMAO)防治HF。本文基于“心-肠轴”的经典理论,结合现代医学知识,探讨中医药通过调节肠道菌群防治HF的研究现状及前景。Intestinal flora imbalance exists in patients with heart failure(HF).In HF patients,intestinal wall permeability increases,intestinal microbiota and metabolites are disturbed,and then inflammation occurs to further aggravate HF.Traditional Chinese medicine can prevent and treat HF by regulating intestinal bacterial metabolites(TMAO).Based on the classical theory of"heart and small intestine"and modern medical knowledge,this paper discusses the research status and prospect of traditional Chinese medicine in the prevention and treatment of chronic HF by regulating intestinal flora.

关 键 词：肠道菌群 心力衰竭 中医治疗 氧化三甲胺 

分 类 号：R541.61[医药卫生—心血管疾病]