常规治疗无效发生神经梅毒患者预后的影响因素分析  

Analysis of influencing factors on prognosis of neurosyphilis in patients with syphilis conventional treatment ineffective

作　　者：崔文颖[1] 翁文佳 闫俊玲[1] 高艳青[1] Cui Wenying;Weng Wenjia;Yan Junling;Gao Yanqing(Department of Dermatology,Beijing You'an Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院皮肤科,100069

出　　处：《北京医学》2024年第10期837-840,共4页Beijing Medical Journal

摘　　要：目的探讨常规治疗无效发生神经梅毒患者预后的影响因素。方法选取2015年1月至2021年12月首都医科大学附属北京佑安医院常规治疗无效发生神经梅毒的患者72例,根据强化驱梅治疗后的疗效分为无效组(n=16)和有效组(n=56)。采用多因素Cox回归分析神经梅毒患者预后的影响因素。结果72例患者中,男45例,女27例,年龄18~75岁,平均(44.1±13.0)岁。多因素Cox回归分析结果显示,无脑梗死病史(HR=2.796,95%CI:1.162~6.731,P=0.022)、治疗前血清快速血浆反应素试验(rapid plasma reagin test,RPR)滴度越高(HR=1.260,95%CI:1.085~1.462,P=0.002)的神经梅毒患者预后越好。结论脑梗死病史、治疗前血清RPR滴度是常规治疗无效发生神经梅毒患者预后的影响因素,无脑梗死病史、治疗前血清RPR滴度越高,神经梅毒患者的预后越好。Objective To explore rhe influencing factors on prognosis of neurosyphilis in patients with syphilis conventional treatment ineffective.Methods A total of 72 neurosyphilis patients with conventional treatment ineffective in Beijing You'an Hospital,Capital Medical University from January 2015 to December 2021 were selected,and were divided into treatment ineffective group(n=16)and treatment effective group(n=56).The prognostic factors of patients with neurosyphilis was analyzed by multivariate Cox regression.Results Among the 72 patients,there were 45 males and 27 females,aged from 18 to 75 years,with an average age of(44.1±13.0)years.Multivariate Cox regression showed that patients with neurosyphilis who had no history of cerebral infarction(HR=2.796,95%CI:1.162-6.731,P=0.022)and had higher rapid plasma reagin test(RPR)titer before treatment(HR=1.260,95%CI:1.085-1.462,P=0.002)had better prognosis.Conclusions The history of cerebral infarction and serum RPR titer before treatment are the factors influencing the prognosis of patients with neurosyphilis who have conventional treatment ineffective.No history of cerebral infarction and the higher serum RPR titer before treatment,the better prognosis of patients with neurosyphilis.

关 键 词：神经梅毒 脑脊液 血清快速血浆反应素试验 预后 

分 类 号：R759.13[医药卫生—皮肤病学与性病学]