动态监测血清TIM-4、GMP-140、CRP水平在重症肺炎患者疗程中的变化及临床意义  

Dynamic monitoring of the changes in serum levels of TIM-4,GMP-140,and CRP during the treatment of severe pneumonia patients and their clinical significance

作　　者：王晨帆 徐勤福[2] 张兰英 Wang Chen-fan;Xu Qin-fu;Zhang Lan-ying(Department of Respiratory Medicine,Yucheng People's Hospital,Yucheng 476300,Henan,China;Respiratory ICU,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]虞城县人民医院呼吸内科,河南虞城476300 [2]郑州大学第一附属医院呼吸ICU,河南郑州450000

出　　处：《四川生理科学杂志》2024年第12期2604-2607,共4页

基　　金：河南省医学科技攻关联合共建项目(编号:LHGJ20216324)。

摘　　要：目的:研究动态监测血清T细胞免疫球蛋白黏蛋白4(T cell immunoglobulin mucin protein-4,TIM-4)、颗粒膜蛋白140(Granule membrane protein-140,GMP-140)、C反应蛋白(C-Reactive Protein,CRP)水平在重症肺炎患者疗程中的变化及临床意义。方法:选取我院2021年4月至2023年7月收治的79例重症肺炎患者为研究组及79例普通肺炎患者为对照组,评估患者疾病转归;对比两组及不同转归患者血清TIM-4、GMP-140、CRP水平;偏回归分析其与疾病转归的关联性及预测价值。结果:研究组及转归不良患者治疗1 d、3 d、5 d后血清TIM-4、GMP-140、CRP水平均高于对照组及转归良好患者,并发现随临床治疗介入,血清TIM-4、GMP-140、CRP水平呈下降趋势(P<0.05);治疗1 d、5 d时血清TIM-4、GMP-140、CRP水平检测对预测转归不良具有较高的价值及危险度。结论:动态监测重症肺炎患者血浆中TIM-4、GMP-140、CRP水平变化有助于临床病情监测及病情转归评估。Objective:To investigate the changes and clinical significance of serum levels of T cell immunoglobulin mucin protein-4(TIM-4),granule membrane protein-140(GMP-140),and C-reactive protein(CRP)in patients with severe pneumonia during the treatment course.Methods:Seventy-nine patients with severe pneumonia admitted to our hospital from April 2021 to July 2023 were selected as the study group and seventy-nine patients with common pneumonia were selected as the control group,and the patient disease regression was evaluated.TIM-4,GMP-140,and CRP serum levels between two groups and patients with different outcomes were compared.The correlation and predictive value between the above indicators and disease outcomes were analyzed through partial regression analysis.Results:The levels of serum TIM-4,GMP-140,and CRP in the study group and patients with poor outcomes after 1,3,and 5 days of treatment were higher than those in the control group and patients with good outcomes,and it was found that with clinical treatment intervention,the levels of serum TIM-4,GMP-140,and CRP showed a downward trend(P<0.05).The detection of serum TIM-4,GMP-140,and CRP levels at 1 and 5 days of treatment had high value and risk in predicting poor outcomes.Conclusion:Dynamic monitoring of the changes in plasma levels of TIM-4,GMP-140,and CRP in patients with severe pneumonia is helpful for clinical disease monitoring and disease outcome assessment.

关 键 词：T细胞免疫球蛋白黏蛋白4 颗粒膜蛋白140 C反应蛋白 重症肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]