硫酸特布他林联合吸入用布地奈德混悬液治疗支气管肺炎患者患者的疗效及细胞因子、免疫功能观察  

Effect of terbutaline sulfate combined with budesonide suspension for inhalation in the treatment of patients with bronchopneumonia and the impact on cytokines and immune function

作　　者：陈觉惠 贺晶晶 刘晓萍 Chen Jue-hui;He Jing-jing;Liu Xiao-ping(Department of Pharmacy,Jinggangshan People's Hospital,Ji'an 343600,Jiangxi,China)

机构地区：[1]井冈山市人民医院药剂科,江西吉安343600

出　　处：《四川生理科学杂志》2024年第12期2718-2720,共3页

摘　　要：目的:观察硫酸特布他林联合吸入用布地奈德混悬液治疗支气管肺炎患者的疗效及对细胞因子、免疫功能的影响。方法:选取2023年1月至2024年6月前来我院诊治的64例支气管肺炎患者作为研究对象,按照随机数表法将其分为对照组和联合组,各32例。对照组患者吸入用布地奈德混悬液治疗,联合组患者在此基础上联合硫酸特布他林治疗。比较两组患者治疗效果,治疗前后炎性因子[C反应蛋白(C-reaction protein,CRP)、白细胞(White blood cell,WBC)]水平、免疫指标(T淋巴细胞CD3^(+)、CD4^(+)/CD8^(+))水平及不良反应。结果:联合组治疗总有效率明显高于对照组(P<0.05)。治疗后,两组患者CRP、WBC水平均明显下降,且联合组均明显低于对照组(P<0.05);两组患者CD3^(+)、CD4^(+)/CD8^(+)水平均明显升高,且联合组均明显高于对照组(P<0.05)。两组患者不良反应发生率无明显差异(P>0.05)。结论:硫酸特布他林联合吸入用布地奈德混悬液治疗支气管肺炎患者疗效较好,能降低患者炎症因子水平,提高免疫能力,安全性好。Objective:To observe the effect of terbutaline sulfate combined with budesonide suspension for inhalation in the treatment of patients with bronchopneumonia,and the impact on cytokines and immune function.Methods:Sixty-four patients with bronchopneumonia treated in the hospital from January 2023 to June 2024 were selected,and divided into a control group(32 cases)and a combination group(32 cases)according to the random number table.The former was treated with budesonide suspension for inhalation,and the latter was treated with terbutaline sulfate on this basis.The two groups were compared in terms of treatment outcomes,the levels of inflammatory factors[C-reactive protein(CRP)and white blood cells(WBC)],immune indicators[T lymphocytes(CD3^(+)and CD4^(+)/CD8^(+))],and adverse reactions.Results:Compared to control group,the total effective rate of combination group was higher(P<0.05).After treatment,the levels of CRP and WBC in both groups decreased,and the levels were lower in combination group(P<0.05).After treatment,the levels of CD3^(+)and CD4^(+)/CD8^(+)in both groups increased,and the levels were higher in combination group(P<0.05).There were more patients with adverse reactions in the control group,but the difference was not statistically significant(P>0.05).Conclusion:The combined treatment with terbutaline sulfate and budesonide suspension for inhalation is effective for patients with bronchopneumonia.It can lower the levels of inflammatory factors,improve immune function,and is safe.

关 键 词：支气管肺炎 吸入用布地奈德混悬液 硫酸特布他林 炎症因子 免疫功能 

分 类 号：R725.6[医药卫生—儿科]