ApoA-1、Apo-B及Apo-A1/Apo-B与缺血性脑卒中患者颈动脉粥样硬化的相关性分析  

Correlation of ApoA-1,Apo-B and Apo-A1/Apo-B with carotid atherosclerosis in patients with ischemic stroke

作　　者：程国祥 Cheng Guo-xiang(Department of Laboratory Medicine,Dexing Traditional Chinese Medicine Hospital,Dexing 334200,Jiangxi,China)

机构地区：[1]江西省德兴市中医院检验科,江西德兴334200

出　　处：《四川生理科学杂志》2024年第12期2791-2793,共3页

摘　　要：目的:探究载脂蛋白(ApoA)-1、Apo-B及Apo-A1/Apo-B与缺血性脑卒中患者颈动脉粥样硬化(CAS)的相关性分析。方法:选择2022年8月-2024年8月江西省德兴市中医院收治的缺血性脑卒中患者76例,根据颈动脉内膜中层厚度(IMT)分为无CAS组16例、IMT增厚组12例、斑块组48例,检测三组患者ApoA-1、Apo-B水平,计算Apo-A1/Apo-B比值,分析组间差异。结果:三组患者血清ApoA-1水平比较,在统计学上差异无统计学意义(P>0.05);血清Apo-B水平由低到高依次为无CAS组、IMT增厚组、斑块组,Apo-A1/Apo-B比值由低到高依次为斑块组、IMT增厚组、CAS组,在统计学上差异有统计学意义(P<0.05);Spearman相关分析显示,缺血性脑卒中患者Apo-B水平与IMT值正相关(r=0.647,P<0.001),Apo-A1/Apo-B比值与IMT值负相关(r=-0.562,P<0.001)。结论:缺血性脑卒中伴CAS患者血清Apo-B水平升高、Apo-A1/Apo-B比值降低,二者水平变化参与患者CAS形成过程,与IMT值密切相关。Objective:To investigate the correlation between apolipoprotein(ApoA)-1,Apo-B and Apo-A1/Apo-B and carotid atherosclerosis(CAS)in patients with ischemic stroke.Methods:Totally 76 patients with ischemic stroke were admitted to Dexing Traditional Chinese Medicine Hospital in Jiangxi Province from August 2022 to August 2024.According to the carotid intima-media thickness(IMT),the above patients were divided into non-CAS group(16 cases),IMT thickening group(12 cases)and plaque group(48 cases).The levels of ApoA-1 and Apo-B in the three groups were detected,and the Apo-A1/Apo-B ratio was calculated,and the differences were analyzed.Results:There was no statistical significance in serum ApoA-1 level among the three groups(P>0.05).Serum Apo-B level successively from low to high revealed non-CAS group,IMT thickening group and plaque group,and Apo-A1/Apo-B ratio from low to high was manifested as plaque group,IMT thickening group and CAS group(P<0.05).Spearman correlation analysis indicated that Apo-B level was positively correlated with IMT(r=0.647,P<0.001)and Apo-A1/Apo-B level was negatively correlated with IMT(r=-0.562,P<0.001)in patients with ischemic stroke.Conclusion:The level of serum Apo-B in patients with ischemic stroke complicated with CAS is increased while the Apo-A1/Apo-B ratio is decreased.The changes of the two levels are involved in the formation of CAS in patients and are closely related to IMT.

关 键 词：载脂蛋白A1 载脂蛋白B Apo-A1/Apo-B 缺血性脑卒中 颈动脉粥样硬化 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]