不同剂量纳布啡联合丙泊酚在无痛宫颈恶性肿瘤三维后装放射治疗中的临床应用研究  

Clinical application of different doses of nalbuphine combined with propofol in painless three-dimensional after loading radiotherapy for cervical malignant tumors

作　　者：吴开恩 汪美容 徐芳[1] Wu Kai-en;Wang Mei-rong;Xu Fang(Department of Anesthesiology,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China;Department of Obstetrics and Gynecology,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)

机构地区：[1]江西省妇幼保健院麻醉科,江西南昌330006 [2]江西省妇幼保健院妇产科,江西南昌330006

出　　处：《四川生理科学杂志》2024年第12期2794-2796,共3页

摘　　要：目的:探究不同剂量纳布啡联合丙泊酚在无痛宫颈恶性肿瘤三维后装放射治疗中的临床应用。方法:选取2023年12月至2024年5月江西省妇幼保健院收治的60例行无痛宫颈恶性肿瘤三维后装放射治疗患者为研究对象。按照随机数字表法分为A组(30例)、B组(30例),分别予以低剂量纳布啡(0.1 mg/kg)、高剂量纳布啡(0.2 mg/kg)与丙泊酚联合麻醉。比较两组患者麻醉诱导前(T0)、手术开始时(T1)、手术开始后10min(T2)、手术结束时(T3)平均动脉压(MAP)、心率(HR)以及血氧饱和度(SPO_(2)),并记录两组患者苏醒时间、离床活动时间,并运用视觉模拟评分法(VAS)评估两组患者术后1 h、2 h疼痛程度、术后不良反应情况。结果:T1、T2、T3时B组MAP指标高于A组,SPO_(2)水平均低于A组(P<0.05);B组患者术后苏醒时间及离床活动时间均长于A组(P<0.05),两组患者术后1 h、2 h VAS评分差异无统计学意义(P>0.05);B组不良反应率高于A组(P<0.05)。结论:在无痛宫颈恶性肿瘤三维后装放射治疗中0.1mg/kg和0.2mg/kg纳布啡分别与丙泊酚联合使用均能达到较好的镇痛效果,但前者术后恢复时间更短,安全性更高,相对更具推荐价值。Objective:To observe the clinical application of different doses of nalbuphine combined with propofol in painless three-dimensional after loading radiotherapy for cervical malignant tumors.Methods:Sixty patients who underwent painless three-dimensional after loading radiotherapy for cervical malignant tumors at Jiangxi Maternal and Child Health Hospital from December 2023 to May 2024 were selected as the study subjects.According to the random number table method,they were divided into group A(30 cases)and group B(30 cases),receiving anesthesia with low-dose(0.1mg/kg)nalbuphine combined with propofol and anesthesia with high-dose(0.2mg/kg)nalbuphine combined with propofol,respectively.Mean arterial pressure(MAP),heart rate(HR)and blood oxygen saturation(SPO_(2))before anesthesia induction(T0),at the beginning of surgery(T1),at 10 min after the beginning of surgery(T2)and at the end of surgery(T3)were compared between the groups.Wake-up time and time for off-bed activities were recorded.The Visual Analog Scale(VAS)was used to evaluate pain degree at 1 hour and 2 hours after surgery.Adverse reactions were observed.Results:At T1,T2 and T3,group B had higher MAP and lower SPO_(2) than group A(P<0.05).Postoperative wake-up time and time for off-bed activities of group B were longer than those of group A(P<0.05).The two groups had comparable VAS scores at 1 hour and 2 hours after surgery(P>0.05).The incidence of adverse reactions in group B was higher than that in group A(P<0.05).Conclusion:0.1mg/kg and 0.2mg/kg of nalbuphine separately combined with propofol both can achieve good analgesic effects in painless three-dimensional after loading radiotherapy for cervical malignant tumors.However,postoperative recovery time of patients receiving the former anesthesia method is shorter,and it is safer.

关 键 词：纳布啡 丙泊酚 宫颈恶性肿瘤 三维后装放射治疗 

分 类 号：R614[医药卫生—麻醉学] R737.3[医药卫生—外科学]