“补肾活血”方改善脑小血管病患者信息处理速度  

The“Bushen Huoxue”Prescription Improves the Information Processing Speed of Patients with Cerebral Small Vessel Disease

作　　者：范欣[1] 郝家乐 罗乐 吴晓翠 张兴坤[1] 张勉之 冯丽莎[1] FAN Xin;HAO Jiale;LUO Le;WU Xiaocui;ZHANG Xingkun;ZHANG Mianzhi;FENG Lisha(Tianjin Academy of Traditional Chinese Medical Affiliated Hospital,Tianjin 300120,China)

机构地区：[1]天津市中医药研究院附属医院,天津300120

出　　处：《中医药临床杂志》2024年第12期2363-2368,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：天津市科技计划项目(18ZXDBSY00080);天津市中医药研究院附属医院科研课题项目(2020015)。

摘　　要：目的:探讨“补肾活血”方改善脑小血管病轻度认知障碍患者信息处理速度的临床研究。方法:选取符合标准的176例“肾精亏虚合瘀血阻络型”脑小血管病轻度认知功能障碍患者,分为治疗组91例和对照组85例。治疗组患者接受补肾活血中药治疗3个月,2组患者均随访1年;比较2组患者整体认知、信息处理速度和步态变化。结果:2组患者年龄、性别、教育水平均无统计学差异。经3个月治疗,中药组患者认知整体水平较前升高,连线试验、步态试验完成时间较前缩短(P<0.05)。随访1年,中药组患者认知整体水平较治疗前稍有提高(P<0.05);对照组患者在连线试验完成时间、步态测试完成时间均较中药组延长(P<0.05)。结论:补肾活血治疗可改善患者整体认知功能及信息处理速度,并且延缓患者1年信息处理速度下降程度。Objective:To explore the clinical study of“Bu Shen Huo Xue”prescription in improving the information processing speed of patients with mild cognitive impairment of cerebral small vessel disease.Methods:A total of 176 patients with mild cognitive impairment of cerebral small vessel disease of“kidney essence deficiency combined with blood stasis and obstruction of collaterals”who met the criteria were selected and divided into a treatment group of 91 cases and a control group of 85 cases.The patients in the treatment group received Bu Shen Huo Xue Chinese medicine treatment for 3 months,and the patients in both groups were followed up for 1 year;the overall cognition,information processing speed and gait changes of the two groups were compared.Results:There was no statistical difference in age,gender and education level between the two groups.After 3 months of treatment,the overall cognitive level of the patients in the Chinese medicine group was higher than before,and the completion time of the line connection test and gait test was shorter than before(P<0.05).After 1 year of follow-up,the overall cognitive level of the patients in the Chinese medicine group was slightly improved compared with before treatment(P<0.05);the completion time of the line connection test and gait test of the patients in the control group was longer than that of the Chinese medicine group(P<0.05).Conclusion:Kidney-tonifying and blood-activating therapy can improve patients’overall cognitive function and information processing speed,and delay the decline of patients’information processing speed in 1 year.

关 键 词：补肾活血 脑小血管病 认知功能障碍 信息处理速度 步态 

分 类 号：R255.3[医药卫生—中医内科学]