基于光子晶体等结构色材料的辐射剂量计设计  

Radiation dosimeter design based on photonic crystals and other structure color materials

作　　者：何志维 王志浩 汤明硕 王运龙 HE Zhiwei;WANG Zhihao;TANG Mingshuo;WANG Yunlong(School of Materials Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 230026,China)

机构地区：[1]南京航空航天大学材料科学与技术学院,南京230026

出　　处：《辐射研究与辐射工艺学报》2024年第6期32-43,共12页Journal of Radiation Research and Radiation Processing

基　　金：江苏省自然科学基金(BK20242043);国家自然科学基金(22006067);国家重点研发计划(2022YFB1902900);中央高校基本科研业务费(NZ2024038);南京航空航天大学研究生创新实践项目(xcxjh20230618)。

摘　　要：本文介绍了近期基于光子晶体等结构色材料的新型三维辐射剂量计的研究进展。光子晶体和结构色材料因其光子带隙特性和明亮的结构色,在医学检测、平面印刷和防伪识别等领域有广泛应用。利用光子晶体材料对电离辐射的响应性,开发了一种能在X或γ射线照射下实现布拉格吸收峰全可见光谱移动的光子晶体薄膜剂量计。该剂量计具有高度可调的应用范围和优于30μm的空间分辨率,对光、温度和湿度表现出良好的环境稳定性。研究还提出了3种读取方式:光谱仪检测、肉眼对比标准色卡和基于手机的色调值检测技术。此外,通过添加聚乙二醇(PEG)作为辐射敏感材料,提高了光子晶体剂量计的灵敏度。进一步地,采用甲基丙烯酸明胶(GelMA)制备水凝胶薄膜,通过化学修饰引入不饱和乙烯基团,实现了对X射线的灵敏响应。该水凝胶光子晶体剂量计在临床放疗设备上展现出良好的剂量响应性能,与商业胶片剂量计的测量结果具有很好的一致性。最后,将3D打印技术与光子晶体剂量计相结合,实现了水凝胶光子晶体剂量计的三维化,为临床放射治疗提供了地形剂量映射的转化潜力。新型的薄膜型光学干涉薄膜的研发也出现,且研究中改性双键、二硫/二硒/二碲及偶氮等辐射响应基团的引入,使得其灵敏度亦得到大幅提升,并实现了X射线辅助下的药物释放。该研究为开发便携、实时、宽范围及高空间分辨率的光子晶体辐射剂量计奠定了理论与技术基础,尽管距离实际的医学放疗剂量验证还有一定距离,但已展现出一定的应用潜力。This article reviews recent studies on three-dimensional(3D)radiation dosimeter designs based on photonic crystals and other structure color materials.Photonic crystals and other structure color materials have a wide range of applications in fields such as medical detection,graphic printing,and anti-counterfeiting identification owing to their photonic bandgap properties and bright structural colors.The responsiveness of photonic crystals and other structure color materials to ionizing radiation has been exploited to develop a photonic crystal thin-film dosimeter than can achieve a full visible spectral shift of Bragg absorption peaks under X-orγ-ray irradiation.The dosimeter has a highly tunable application range and a spatial resolution exceeding 30μm;moreover,it exhibits high environmental stability to light,temperature,and humidity.This study proposes three reading methods:spectrometer detection,naked-eye comparison with standard color cards,and mobile phone-based hue-value detection techniques.Additionally,the sensitivity of the photonic crystal dosimeter was improved by adding polyethylene glycol as a radiation-sensitive material.Gelatin methacrylate was used to prepare hydrogel films,which were chemically modified to introduce unsaturated vinyl groups to achieve sensitive response to X-rays.The hydrogel photonic crystal dosimeter demonstrated favorable dose-response performance on clinical radiotherapy equipment,which agrees well with the measurement results of commercial film dosimeters.Finally,the photonic crystal dosimeter was combined with three-dimensional printing technology to three-dimensionalize the hydrogel photonic crystal dosimeter,thus providing translational potential for topographic dose mapping in clinical radiotherapy.Meanwhile,new thin-film optical interference films have emerged,and the introduction of radiation-responsive groups such as modified double bonds,disulfides/diselenides/disulfides,and azo groups significantly improved their sensitivity and enabled simultaneous drug release

关 键 词：光子晶体 辐射剂量计 3D打印 水凝胶 剂量验证 

分 类 号：TL13[核科学技术—核能科学]