支气管扩张症的发病因素和分子机制研究进展  

Research progress on pathogenesis and molecular mechanism of bronchiectasis

作　　者：丁荣 宋小莲[1] DING Rong;SONG Xiaolian(Shanghai Tenth People's Hospital Clinical Medical College of Nanjing Medical University,Shanghai 200072,China;The Fourth People's Hospital of Taizhou,Taizhou 225300,Jiangsu Province,China)

机构地区：[1]南京医科大学,上海十院临床医学院,上海200072 [2]泰州市第四人民医院,江苏泰州225300

出　　处：《同济大学学报（医学版）》2024年第6期919-925,共7页Journal of Tongji University(Medical Science)

基　　金：申康三年行动计划重大临床研究项目(SHDC2020CR3068B);上海市崇明区科学技术委员会项目(CKY2023-41)。

摘　　要：支气管扩张症的发病率逐年上升,但当前的治疗策略仍然有限,并且伴随着一定的副作用。因此,深入探索与支气管扩张症相关的风险因素和致病机制,对于优化临床治疗策略具有重要意义。本文综述了支气管扩张症的主要风险因素,包括其他疾病、细菌与微生物、炎症以及遗传因素等。同时,文章详细阐述了这些风险因素如何通过炎症、免疫缺陷和上皮细胞功能障碍等途径导致支气管扩张症的发生。这些发现为后续机制研究和疾病治疗提供了新的理论依据。The incidence of bronchiectasis is increasing,but current treatment strategies are still limited and accompanied by certain side effects.Therefore,in-depth exploration of the risk factors and pathogenic mechanisms associated with bronchiectasis is of great significance for optimizing clinical treatment strategies.This article reviews the main risk factors for bronchiectasis,including comorbidities,inflammation,pathogenic microorganisms,and genetic factors;and the mechanisms of these risk factors in the development of bronchiectasis including inflammation,immune deficiency and epithelial cell dysfunction.Hopefully these findings would contribute to the development of new treatment strategies of bronchiectasis.

关 键 词：支气管扩张症 风险因素 致病机制 炎症因子 

分 类 号：R562[医药卫生—呼吸系统]