血清CRP、WBC、PCT、CD64指数联合检验在妇科感染性疾病中的诊断价值  

Diagnostic Value of Combined Detection of Serum CRP,WBC,PCT and CD64 Index in Gynecological Infectious Diseases

作　　者：熊玉良 李强 XIONG Yuliang;LI Qiang(Department of Clinical Laboratory,Yudu County Maternal and Child Health Hospital,Yudu 342300,Jiangxi,China)

机构地区：[1]于都县妇幼保健院检验科,江西于都342300

出　　处：《医学信息》2024年第24期133-136,共4页Journal of Medical Information

摘　　要：目的探讨血清C反应蛋白(CRP)、白细胞计数(WBC)、降钙素原(PCT)、白细胞分化抗原64(CD64)指数联合检验在妇科感染性疾病中的诊断价值。方法选取2022年6月-2024年10月于都县妇幼保健院收治的60例妇科感染性疾病患者作为研究对象,将经病原学检查确诊细菌感染的35例患者设为细菌组,将真菌感染的25例患者设为真菌组,另选同期于本院接受健康体检的30例体检者为对照组,所有受检者均行血清CRP、WBC、PCT、CD64指数检测。比较三组及不同类型妇科感染性疾病患者血清CRP、WBC、PCT、CD64指数水平,以血培养结果为金标准,分别分析CRP、WBC、PCT、CD64指数单独与联合检测妇科感染性疾病的灵敏度、特异度、准确度以及阳性、阴性预测值。结果细菌组、真菌组血清CRP、WBC、PCT、CD64指数水平均高于对照组,且细菌组血清CRP、WBC、CD64指数水平均高于真菌组(P<0.05);而细菌组、真菌组PCT水平比较,差异无统计学意义(P>0.05)。附件炎患者CRP水平最高,子宫内膜炎患者PCT水平最高,阴道炎患者WBC水平最高,宫颈糜烂患者CD64指数最高。PCT、CRP、CD64指数和WBC联合检测妇科感染性疾病的特异度、敏感度、阳性预测值、阴性预测值及准确率均高于4项指标单独检测(P<0.05)。结论血清CRP、WBC、PCT、CD64指数联合检验在诊断妇科感染性疾病中的应用价值较高,可获得较高的诊断敏感度及特异度,为临床诊断此类疾病及后续制定治疗方案制定提供可靠证据,值得应用。Objective To investigate the diagnostic value of combined detection of serum C-reactive protein(CRP),white blood cell count(WBC),procalcitonin(PCT)and white blood cell differentiation antigen 64(CD64)index in gynecological infectious diseases.Methods A total of 60 patients with gynecological infectious diseases admitted to Yudu County Maternal and Child Health Hospital from June 2022 to October 2024 were selected as the research objects.35 patients with bacterial infection diagnosed by etiological examination were set as bacterial group,and 25 patients with fungal infection were set as fungal group.Another 30 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.All subjects underwent serum CRP,WBC,PCT and CD64 index detection.The levels of serum CRP,WBC,PCT and CD64 index in three groups and patients with different types of gynecological infectious diseases were compared.With the results of blood culture as the gold standard,the sensitivity,specificity,accuracy,positive and negative predictive values of CRP,WBC,PCT and CD64 index alone and combined detection of gynecological infectious diseases were analyzed.Results The levels of serum CRP,WBC,PCT and CD64 index in the bacterial group and the fungal group were higher than those in the control group,and the levels of serum CRP,WBC and CD64 index in the bacterial group were higher than those in the fungal group(P<0.05),while there was no significant difference in PCT level between the bacterial group and the fungal group(P>0.05).CRP level was the highest in patients with adnexitis,PCT level was the highest in patients with endometritis,WBC level was the highest in patients with vaginitis,and CD64 index was the highest in patients with cervical erosion.The specificity,sensitivity,positive predictive value,negative predictive value and accuracy of PCT,CRP,CD64 index and WBC combined detection of gynecological infectious diseases were higher than those of the four indexes alone(P<0.05).Conclusion

关 键 词：CRP WBC PCT CD64指数 妇科感染性疾病 

分 类 号：R446[医药卫生—诊断学]