巴蜀颗粒止咳祛痰平喘作用实验研究  

Experimental Study on Antitussive,Expectorant and Antiasthmatic Effects of Bashu Granules

作　　者：王晓敏 陈伟 刘瑞 古丽再帕尔·托合尼亚孜 马芹 Wang Xiaomin;Chen Wei;Liu Rui;Gvlzapar Tohniyaz;Ma Qin(Xinjiang Huashidan Drug Research Co.,Ltd.,Urumqi 830011,China;Key Laboratory of Bone Health Traditional Chinese Medicine Research and Development Corps,Urumqi 830011,China)

机构地区：[1]新疆华世丹药物研究有限责任公司,新疆乌鲁木齐830011 [2]骨健康中医药研发兵团重点实验室,新疆乌鲁木齐830011

出　　处：《亚太传统医药》2025年第1期17-22,共6页Asia-Pacific Traditional Medicine

基　　金：新疆维吾尔自治区地州科学基金(2022D01F50);新疆维吾尔自治区创新环境(人才、基地)建设专项——自然科学基金项目(2023D01F31);新疆维吾尔自治区“十四五”重大科技专项(2022A03017-3);新疆生产建设兵团科技创新人才计划项目(2023CB002)。

摘　　要：目的:探讨巴蜀颗粒的止咳祛痰平喘作用。方法:采用豚鼠枸橼酸引咳试验和小鼠氨水引咳试验观察巴蜀颗粒的止咳作用;采用大鼠气管排痰试验和小鼠气管酚红排泌试验观察其祛痰作用;通过豚鼠氯化乙酰胆碱和磷酸组胺引喘试验观察其平喘作用。结果:巴蜀颗粒可明显延长豚鼠及小鼠咳嗽潜伏期、减少咳嗽次数,可明显增加大鼠排痰量和小鼠气管酚红排泌量。在豚鼠氯化乙酰胆碱和磷酸组胺引喘模型中,给药后豚鼠引喘潜伏期明显延长,肺脏病变积分明显降低,组织病理学检查结果显示巴蜀颗粒对哮喘模型豚鼠肺脏组织的炎细胞浸润、充血、肺泡扩张和动脉肥大等病变有明显改善作用。结论:巴蜀颗粒具有明显的止咳、祛痰、平喘作用。Objective:To explore the antitussive,expectorant,and antiasthmatic effects of Bashu Granules.Methods:The antitussive effects of Bashu Granules were observed by citric acid induced cough test in guinea pigs and ammonia induced cough test in mice;The expectorant effects were observed using tracheal sputum excretion test in rats and tracheal phenol red secretion test in mice;The antiasthmatic effect was observed by the asthmatic test of acetylcholine chloride and histamine phosphate in guinea pigs.Results:Bashu Granules can significantly prolong the cough latency of guinea pigs and mice,reduce the cough frequency in guinea pigs and mice,and significantly increase the sputum output of rats and the secretion of phenol red in the trachea of mice.In the guinea pig asthma model induced by acetylcholine chloride and histamine phosphate,the asthma inducing latency of guinea pigs was significantly prolonged after administration,and the lung lesion score was significantly reduced.The histopathological examination showed that Bashu Granules had significantly improved the inflammatory cell infiltration,congestion,alveolar dilatation,arterial hypertrophy and other lesions in the lung tissue of asthma model guinea pigs.Conclusion:Bashu Granules have obvious antitussive,expectorant,and asthma relieving effects.

关 键 词：巴蜀颗粒 止咳 祛痰 平喘 

分 类 号：R285.5[医药卫生—中药学]