基于《中华医典》脱发治疗方剂用药规律挖掘及医院制剂开发组方探析  

Analysis of Prescription Patterns for Alopecia Treatment Based on Chinese Medical Classics and Exploration of Hospital Preparation Formulations

作　　者：马小兵[1] 刘文武[1] 张小波[1] 王世贵[1] 汪欢 佘金燕 Ma Xiaobing;Liu Wenwu;Zhang Xiaobo;Wang Shigui;Wang Huan;She Jinyan(Department of Pharmacy,Suizhou Traditional Chinese Medicine Hospital,Suizhou 441300,China)

机构地区：[1]随州市中医医院药学部,湖北随州441300

出　　处：《亚太传统医药》2025年第1期127-133,共7页Asia-Pacific Traditional Medicine

基　　金：湖北省中医药管理局2023-2024年度中医药科研项目(ZY2023F112)。

摘　　要：目的:基于中医古籍数据挖掘,探讨中药治疗脱发的用药规律,并结合中药制剂技术探索治疗脱发的医院制剂。方法:按照纳入和排除标准筛选《中华医典》中治疗脱发的方剂,使用“古今医案云平台”分析药物的用药频次、中药属性(四气、五味、性味、归经)、关联规则、聚类分析,并结合数据分析结果和传统制剂技术要求初步拟定治疗脱发的医院制剂处方。结果:纳入内服方剂38首,外用方剂84首。药物性多温或微温,味以甘、辛为主,归经多入肝肾脾经。口服润肠通便、扶正解毒;外用行气祛风,解表散寒。聚类分析得到内服和外用基础方各2首,结合现代医院制剂要求、用药特点等初步拟定医院制剂新方3个。结论:探析治疗脱发方剂用药规律以用于医院制剂组方切合中医药基础理论,符合现代治疗脱发的用药思维。Objective:To investigate the medication patterns of Traditional Chinese Medicine(TCM)in treating alopecia through data mining of ancient Chinese medical texts,and to explore hospital preparation formulations for alopecia treatment in conjunction with modern TCM pharmaceutical technology.Methods:Prescriptions for alopecia treatment were selected from the Chinese Medical Code based on inclusion and exclusion criteria.The“Ancient and Modern Medical Cases Cloud Platform”was used to analyze drug frequency,TCM properties(four natures,five flavors,nature and flavor,meridian tropism),association rules,and cluster analysis.Based on the data analysis results and traditional preparation technology requirements,preliminary hospital preparation prescriptions for alopecia treatment were formulated.Results:38 oral prescriptions and 84 external use prescriptions were included.The majority of herbs were warm or slightly warm in nature,with sweet and pungent flavors,primarily entering the liver,kidney,and spleen meridians.Oral preparations mainly functioned to moisten the intestines,promote bowel movement,strengthen the body,and detoxify.External preparations primarily acted to promote qi circulation,dispel wind,release the exterior,and disperse cold.Cluster analysis yielded two basic formulas each for oral and external use.Combining modern hospital preparation requirements and medication characteristics,three new hospital preparation formulas were preliminarily developed.Conclusion:The medication patterns of alopecia treatment prescriptions applied to hospital preparation formulations align with fundamental TCM theory and conform to modern therapeutic concepts for alopecia treatment.

关 键 词：脱发 《中华医典》 古今医案云平台 用药规律 制剂组方 

分 类 号：R275.9[医药卫生—中西医结合]