基于肠道菌群机制探究2型糖尿病“二阳结谓之消”理论内涵  

Underlying Significance of the "Two Yang Junctions Are Called Elimination" Theory in Type 2 Diabetes Based on the Metabolic Mechanisms of Intestinal Flora

作　　者：刘婧 邬倩颖 苏冠旬 吴恩行 王世东[1] LIU Jing;WU Qianying;SU Guanxun;WU Enhang;WANG Shidong(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中医药导报》2024年第12期111-114,123,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京中医药大学东直门医院2024科技创新专项(DZMKJCX-2024-005);国家重点研发计划(2018YFC1704402)。

摘　　要：“二阳结谓之消”是2型糖尿病的核心病机之一,现代研究证实2型糖尿病与肠道菌群失调相关。菌群失调所介导的慢性炎症反应和肠道屏障受损与2型糖尿病所致的内热、气虚状态契合,验证了“二阳结谓之消”病机的生物学基础,为探究其理论内涵提供了新的视角。通过探究肠道菌群机制与2型糖尿病“二阳结谓之消”理论的相关性,丰富“二阳结谓之消”科学内涵,确立清热散结、益气补虚治法,为从“二阳结谓之消”论治2型糖尿病提供参考。The theory of "two yang junctions are called elimination" is one of the core mechanisms of type 2 diabetes.Modern studies have confirmed that type 2 diabetes is associated with intestinal dysbiosis.The chronic inflammatory response and impaired intestinal barrier mediated by intestinal dysbiosis are highly compatible with the state of internal heat and qi deficiency caused by type 2 diabetes mellitus,which verifies the biological basis of the disease mechanism of "two yang junctions are called elimination",and provides new perspectives for exploring its theoretical connotations.Therefore,by exploring the correlation between the mechanism of intestinal flora and the theory of type 2 diabetes mellitus,we can enrich the theoretical implications of "two yang junctions are called elimination",establish the treatment method of clearing heat and dispersing junction,benefiting qi and replenishing deficiency,and provide references for the treatment of type2 diabetes mellitus from the theory of "two yang junctions are called elimination".

关 键 词：2型糖尿病 二阳结谓之消 肠道菌群 慢性炎症 肠道屏障 

分 类 号：R255.4[医药卫生—中医内科学]