骨骼肌干细胞及其微环境调控肌少症的研究进展  

Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review

作　　者：高天 张勇 张丹[1] 曾平 GAO Tian;ZHANG Yong;ZHANG Dan;ZENG Ping(Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China;Health and Medical Department,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)

机构地区：[1]山东中医药大学中医药创新研究院,济南250355 [2]中国医学科学院、北京协和医学院、基础医学研究所生物化学与分子生物学系,北京100005 [3]中国医学科学院、北京协和医学院、北京协和医院保健医疗部,北京100730

出　　处：《中国医学科学院学报》2024年第6期958-964,共7页Acta Academiae Medicinae Sinicae

摘　　要：肌少症是以骨骼肌质量减少和功能下降为主要特征的临床综合征。肌少症患者易跌倒、骨折、增加住院率,严重降低老龄人群的生活质量,是老龄化社会面临的主要健康问题之一。骨骼肌干细胞,也称为肌卫星细胞,对于骨骼肌再生和稳态维持至关重要。研究表明骨骼肌微环境信号对骨骼肌干细胞功能具有重要调控作用。其中,骨骼肌纤维作为骨骼肌干细胞的直接微环境,调控骨骼肌干细胞的激活、增殖和自我更新。本文主要综述骨骼肌干细胞及其微环境调控肌少症的研究进展,为深入探讨通过改善骨骼肌微环境进而调控骨骼肌干细胞功能靶向治疗肌少症提供理论支持。Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly’s ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.Skeletal muscle stem cells,also known as muscle satellite cells,play a key role in supporting muscle regeneration and homeostasis maintenance.Studies have suggested that muscle satellite cell functions are tightly regulated by microenvironment signals in the skeletal muscle.Of note,skeletal muscle fibers,serving as an immediate niche of muscle satellite cells,regulate their activation,proliferation,and self-renewal.This article reviews the research progress in the regulatory roles of skeletal muscle stem cells and their microenvironment in sarcopenia during aging,providing theoretical support for potential treatment of sarcopenia via modifying skeletal muscle microenvironment and regulating muscle satellite cell functions.

关 键 词：肌少症 骨骼肌干细胞 肌卫星细胞 微环境 

分 类 号：R34[医药卫生—基础医学]