Effect and Mechanism of Action of BMSC-derived Exosomes on Gas Explosion-induced Blast Lung Injury  

作　　者：Xiaoying Li Jing He Meng Deng Hui Fan Xiaofei Jin Xuedan Deng Wenjie Ren Sanqiao Yao Wu Yao Changfu Hao 

机构地区：[1]Department of Occupational Health and Environmental Health,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China [2]Xingtai Medical College,Xingtai 054000,Hebei,China [3]The Sixth People’s Hospital of Zhengzhou,Zhengzhou 450000,Henan,China [4]Department of Ultrasound,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450015,Henan,China [5]School of Public Health,Xinxiang Medical University,Xinxiang 453000,Henan,China [6]Department of Child and Adolescence Health,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China

出　　处：《Biomedical and Environmental Sciences》2024年第12期1441-1446,共6页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant no.U190420094).

摘　　要：Gas explosions are one of the most lethal types of coal mine safety accidents.The powerful shock waves these explosions produce can cause damage to the lung tissue of nearby individuals,resulting in symptoms including pulmonary hemorrhage and pulmonary edema[1].At present,there is no effective treatment for gas explosion-induced lung injuries;therefore,there is an urgent need to identify new therapeutic means to improve the clinical management of the system of treatment for lung injury caused by gas explosions.Mesenchymal stem cells(MSCs)are adult stem cells with self-renewal ability and multilineage differentiation potential that exert their therapeutic potential through various mechanisms,including the regulation of inflammation and immune responses[2].Reports on the therapeutic role of MSCs in blast lung injury remain scarce.

关 键 词：LUNG INJURIES LUNG 

分 类 号：R642[医药卫生—外科学]