健脾益肺消积汤联合NP化疗方案对非小细胞肺癌患者的治疗效果  

The therapeutic effect of Jianpi Yifei XiaoJi Decoction combined with NP chemotherapy regimen on NSCLC patients

作　　者：郗业奎 刘同坤 徐百鸿 罗杨敏 XI Yekui;LIU Tongkun;XU Baihong;LUO Yangmin(Department of Preventive Medicine,Puyang Traditional Chinese Medicine Hospital,Puyang 457001,China)

机构地区：[1]濮阳市中医医院治未病科,河南濮阳457001

出　　处：《延安大学学报（医学科学版）》2024年第4期19-23,共5页Journal of Yan'an University:Medical Science Edition

摘　　要：目的分析健脾益肺消积汤联合长春瑞滨^(+)顺铂(navelbine plus Cisplatin,NP)化疗方案对非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗效果。方法选取2021年4月至2023年5月濮阳市中医医院收治的138例NSCLC患者为研究对象,根据治疗方案将患者分为对照组和观察组,各69例。对照组采用NP化疗方案治疗,观察组基于对照组加用健脾益肺消积汤治疗。比较两组临床疗效、毒性及不良反应、治疗前后卡式(Karnofsky,KPS)评分、免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)T淋巴细胞)、血清指标[糖类抗原125(carbohydrate antigen 125,CA125)、癌胚抗原(carcinoembryonic antigen,CEA)、趋化因子配体25(CC chemokine ligand 25,CCL25)、潜在转化生长因子β结合蛋白-2(latent transforming growth factor-βbinding protein 2,LTBP2)]水平。结果治疗后观察组总有效率、KPS评分、免疫功能指标CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)T淋巴细胞均高于对照组,差异均有统计学意义(P<0.05);免疫功能指标CD8^(+)T淋巴细胞,血清CC族指标CA125、CEA、CCL25、LTBP2水平低于对照组,差异有统计学意义(P<0.05);观察组血小板减少、骨髓抑制、白细胞减少、呕吐、恶心、肝功能损伤发生率低于对照组(P<0.05)。结论健脾益肺消积汤联合NP化疗方案治疗NSCLC可提高抗肿瘤效果,改善免疫功能,降低毒性及不良反应发生率,改善机体功能状态。Objective To analyze the therapeutic effect of Jianpi Yifei Xiaoji Decoction combined with navelbine plus Cisplatin(NP)chemotherapy regimen on patients with Non-small cell lung cancer(NSCLC).Methods 138 NSCLC patients admitted to Puyang Traditional Chinese Medicine Hospital from April 2021 to May 2023 were selected as the research subjects.According to the treatment plan,the patients were divided into a control group and an observation group,with 69 cases in each group.The control group was treated with NP chemotherapy regimen,while the observation group was treated with Jianpi Yifei Xiaoji Decoction in addition to the control group.The clinical efficacy,toxic side effects,Karnofsky(KPS)scores before and after treatment,and immune function indicators(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)T lymphocyte),serum marker levels including carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),CC chemokine ligand 25(CCL25),and latent transforming growth factor beta binding protein-2(LTBP2)were compared.Results After treatment,the total effective rate,the KPS and the immune function idicators levels of CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)T lymphocyte of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).After treatment,the levels of CD8^(+)T lymphocyte,and serum marker levels of CA125,CEA,CCL25,and LTBP2 in the observation group were lower than those in the control group,with statistically significant difference(P<0.05);The incidence of thrombocytopenia,bone marrow suppression,leukopenia,vomiting,nausea,and liver function damage in the observation group were lower than those in the control group(P<0.05).Conclusion The combination of Jianpi Yifei Xiaoji Decoction and NP chemotherapy regimen can improve the anti-tumor effect,enhance immune function,reduce the incidence of toxic side effects,and improve the functional status of NSCLC.

关 键 词：健脾益肺消积汤 NP化疗 非小细胞肺癌 毒副反应 

分 类 号：R273[医药卫生—中西医结合] R734.2[医药卫生—中医肿瘤科]