热量限制与间歇性禁食对炎症及代谢疾病的影响  

The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases

作　　者：张熙冰 牛玲 刘方 冉江华[1] Zhang Xibing;Niu Ling;Liu Fang;Ran Jianghua(Department of Hepatobiliary and Pancreatic Surgery,The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming;Department of Endocrinology,The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming,KunmingYunnan 650000,China)

机构地区：[1]昆明医科大学附属甘美医院肝胆胰外科暨昆明市第一人民医院肝胆胰外科 [2]昆明医科大学附属甘美医院内分泌科暨昆明市第一人民医院内分泌科,云南昆明650000

出　　处：《昆明医科大学学报》2024年第12期1-9,共9页Journal of Kunming Medical University

基　　金：国家自然科学基金项目(82060127);春城计划高层次人才培养项目(C202214007)。

摘　　要：热量限制(Caloric Restriction,CR)和间歇性禁食(Intermittent Fasting,IF)作为2种饮食干预策略,近年来因其在调节炎症和代谢紊乱中的潜在作用受到广泛关注。随着高热量饮食和久坐生活方式的普及,肥胖、2型糖尿病、心血管疾病等代谢性疾病的发病率显著增加,给公共卫生带来了严峻挑战。本综述探讨了CR和IF通过代谢重塑、自噬激活及抑制炎症通路等机制,在减少炎症、改善代谢健康中的作用。特别是在多发性硬化、系统性红斑狼疮等炎症性疾病中,这2种策略表现出显著的干预效果。此外,CR和IF在肥胖、糖尿病及心血管疾病的代谢调节中也有积极作用。尽管它们在临床应用中具有潜力,但长期依从性和安全性仍是推广的关键挑战。未来研究应侧重个性化干预和多治疗手段的联合应用,以进一步验证CR和IF的临床价值。综上所述,CR和IF为慢性疾病管理提供了新的非药物策略,具有重要的应用前景。Caloric restriction(CR)and intermittent fasting(IF)are two dietary intervention strategies that have garnered increasing attention for their potential role in regulating inflammation and metabolic disorders.With the widespread adoption of high-calorie diets and sedentary lifestyles,the incidence of metabolic diseases such as obesity,type 2 diabetes,and cardiovascular diseases has risen significantly,posing major public health challenges.This review explores how CR and IF impact inflammation reduction and metabolic health improvement through mechanisms such as metabolic reprogramming,autophagy activation,and inhibition of inflammatory pathways.Notably,both strategies have shown promising intervention effects in inflammatory diseases like multiple sclerosis and systemic lupus erythematosus.Additionally,CR and IF demonstrate positive effects in the metabolic regulation of obesity,diabetes,and cardiovascular diseases.Despite their clinical potential,long-term adherence and safety remain key challenges for widespread implementation.Future research should focus on personalized interventions and the integration of multiple therapeutic approaches to further validate the clinical value of CR and IF.In summary,CR and IF offer novel,non-pharmacological strategies for managing chronic diseases,presenting significant potential for future clinical application.

关 键 词：热量限制 间歇性禁食 免疫性疾病 炎症调节 代谢疾病 

分 类 号：R593[医药卫生—内科学] R589[医药卫生—临床医学]