Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration  

作　　者：Xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu 

机构地区：[1]Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research,Guangyuan Key Laboratory of Multifunctional Medical Hydrogel,Guangyuan Central Hospital,Guangyuan 628000,People’s Republic of China [2]Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Bio‑Functional Materials,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,People’s Republic of China [3]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,People’s Republic of China

出　　处：《Nano-Micro Letters》2025年第3期389-439,共51页纳微快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(51925304);Natural Science Foundation of Sichuan Province(2024NSFSC1023);Medical Research Program of Sichuan Province(Q23015).

摘　　要：Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone regeneration.However,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo.Hydrogels have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological conditions.This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying diseases.Additionally,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential delivery.Finally,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关 键 词：HYDROGEL Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]