纳米氧化铋软膏对放射性皮肤损伤的防护作用  

Protection effects of a nano-bismuth oxide cream against skin injury induced by radiation

作　　者：周晓靓 杨雨薇 刘金剑 唐海康 徐文清 ZHOU Xiaoliang;YANG Yuwei;LIU Jinjian;TANG Haikang;XU Wenqing(State Key Laboratory of Advanced Medical Materials and Devices,Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Tianjin 300192)

机构地区：[1]中国医学科学院、北京协和医学院放射医学研究所,先进医用材料和医疗器械全国重点实验室,天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《辐射防护》2024年第6期711-717,共7页Radiation Protection

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-042);中央高校基本科研业务费(3332022066,3332022067);国家自然科学基金(82203970)。

摘　　要：为了有效防护介入诊疗操作人员的皮肤防护问题,本文研制了一种纳米氧化铋软膏剂实现对介入诊疗中放射性皮肤损伤的保护作用。通过大鼠模型评估纳米氧化铋软膏对40 Gy X射线照射后急性皮肤损伤的预防作用;通过全身照射小鼠造血系统损伤模型,观察该软膏剂对4 Gyγ射线造成的血液系统损伤的预防作用。针对^(125)I在植入放疗的辐射防护问题,通过单光子发射计算机断层扫描仪(Micro-SPECT/CT)成像,比较不同组别小鼠^(125)I的射线透过率。结果表明,氧化铋软膏对急性放射性皮肤损伤以及全身照射造成的血小板减少以及股骨有核细胞降低均有显著预防作用。另外,Micro-SPECT/CT扫描结果显示纳米氧化铋软膏对小鼠体内植入^(125)I产生的γ光子也有很好的辐射屏蔽作用。To protect the skin of interventional therapy operators from radioactive damage,a bismuth oxide nano ointment has been developed.Various proportion of bismuth oxide cream were prepared,through rats model to assess the protetion effect against acute radiation skin injury induced by 40 Gy X-ray exposure.Then the mice exposed to 4 Gyγ-ray TBI induced the hemopoietic system stress,and the prevention effects of the various proportion bismuth oxide creams were analyzed by WBC counts,PLT counts and bone marrow nucleated cells counts.And the radionuclide^(125)I was administrated i.v.to the mice and SPECT scan was performed.The shield efficiency of internal exposure was accessed between the bismuth oxide cream group and vehicle.The prevention of the bismuth oxide cream was observed by application on the skin of rats prior to the 40 Gy X-ray exposure.Various proportion bismuth oxide cream presented significant prevention effects on the hemopoietic system stress induced by 4 Gy gamma-ray TBI.The bismuth oxide cream applied on the skin of mouse effectively blocked the gamma photon generated by^(125)I.

关 键 词：纳米氧化铋 辐射防护 放射性皮肤损伤 软膏剂 

分 类 号：R818.05[医药卫生—放射医学]