某三甲医院2019⁃2022年儿童社区获得性肺炎病原流行病学特征  

Epidemiological characteristics of community⁃acquired pneumonia pathogenesis in children at a tertiary hospital from 2019 to 2022

作　　者：段友红 郭普[2] 梁友宝[1] 常滋毓[1] 陈尧[1] DUAN Youhong;GUO Pu;LIANG Youbao;CHANG Ziyu;CHEN Yao(Department of Laboratory Medicine,Bengbu Children's Hospital,Bengbu,Anhui,China,23000;Department of Laboratory Medicine,The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,China,233000)

机构地区：[1]蚌埠市第一人民医院检验科,安徽蚌埠233000 [2]蚌埠医学院第一附属医院检验科,安徽蚌埠233000

出　　处：《分子诊断与治疗杂志》2024年第12期2265-2269,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省高校自然科学研究重点项目(KJ2021A0761);蚌埠医学院自然科学类科技项目(2022byzd155)。

摘　　要：目的分析蚌埠市第一人民医院2019至2022年儿童社区获得性肺炎(CAP)病原学特征。方法以2019年1月至2022年12月蚌埠市儿童医院入住的8333例CAP患儿为研究对象,采集患儿的鼻咽拭子、痰或静脉血,检测流感病毒A(FluA)、流感病毒B(FluB)、合胞病毒(RSV)、腺病毒(ADV)、副流感病毒1(PIV1)、副流感病毒2(PIV2)和副流感病毒3(PIV3)、细菌和肺炎支原体(MP),并记录患儿的一般临床资料。结果患儿以男童为主(61.27%),1~23月龄患儿占比最高,达到59.33%。冬季入院患儿3348例,占比40.18%,高于其它季节。入院患儿以非重症和良性结局患儿为主;细菌、病毒、MP和合并感染检出总数分别为119(2.17%)、1394(25.44%)、3022(55.15%)、945(17.24%),总病原体检出率为65.76%(5480/8333)。患者数、总细菌数、呼吸道病毒、MP和合并感染数在不同年份间差异有统计学意义(P均<0.05);FluA和PIV3合并感染占自身全部检出率百分比分别为31.58%、31.53%,位居前两位。945例合并感染中,MP合并感染392(41.48%)例,占比最多;2种病原体合并感染901例,占比最高(95.34%),其中合并感染模式又以病毒+MP最多(82.12%);PIV1、PIV2、PIV3、Flu A、RSV、细菌、合并感染检出量在1~23月患儿中显著多于2~4岁和≥5岁儿童,差异有统计学意义(P均<0.05),MP在≥5岁儿童检出量高于其它年龄段,差异有统计学意义(P<0.05),FluB和ADV各年龄段检出量差异无统计学意义(P均>0.05);MP、PIV1、PIV2、PIV3秋季检出最多,FluA、FluB、RSV和细菌冬季检出最多。结论临床诊疗中要注意病原体在不同年龄和季节的检出性差异,以及多种病原体的合并感染。Objective To investigate the pathogenic characteristics of Community Acquired Pneumonia(CAP)in children from 2019 to 2022 at the Fist Peole's Hospital of Benghu city.Methods From Janu⁃ary 2019 to December 2022,a study was conducted on 8,333 children with community⁃acquired pneumonia who were admitted to Bengbu Childrens Hospital.Nasopharyngeal swabs,sputum or venous blood samples were collected from the children and tested for respiratory viruses including Flu A,Flu B,RSV,ADV,PIV1,PIV2,and PIV3,as well as bacteria and MP.The general clinical data of the children were recorded.Results The children were predominantly boys(61.27%),with the highest proportion of children aged 1⁃23 months at 59.33%.In winter,3,348 children were admitted to the hospital,accounting for 40.18%,which was higher than other seasons.Admissions were mainly children with nonsevere and benign outcomes.The total number of bacterial,viral,MP,and coinfections detected was 119(2.17%),1,394(25.44%),3,022(55.15%),and 945(17.24%),respectively.The total pathogen detection rate was 65.76%(5,480/8,333).The differences in the number of patients,total bacteria,respiratory viruses,MP and co⁃infections were statistically significant between years(P<0.05).Coinfections of FluA and PIV3 accounted for 31.85%and 31.53%of their own total detection rate respectively.Among the 945 cases of coinfections,392(41.48%)cases of MP co⁃infec⁃tion were the most common.901 cases of co⁃infections of 2 pathogens accounted for the highest percentage(95.34%),with the most common mode of co⁃infections being viral+MP(82.12%).The number of PIV1,PIV2,PIV3,Flu A,RSV,bacterial,and coinfections detected was significantly higher in children aged 1 to 23 months than that in children aged 2~4 years and≥5 years,and the difference was statistically significant(P<0.05).MP was detected in children≥5 years of age more than in other age groups,and the difference was statistically significant(P<0.05).Flu B and ADV did not show statistically significant differences in detection

关 键 词：儿童社区获得性肺炎 病原 流行病学特征 

分 类 号：R725.6[医药卫生—儿科] R181.3[医药卫生—临床医学]