SAA、ACR及动脉硬化指数检测在高血压早期肾损害中的预测价值及临床意义  

The predictive value and clinical significance of SAA,ACR and arteriosclerosis index in early renal damage in hypertension

作　　者：杨晔娟 刘雨 曹亚冰 梁伟霄 郭春利 YANG Yejuan;LIU Yu;CAO Yabing;LIANG Weixiao;GUO Chunli(Department of Cardiology,Xingtai Central Hospital,Xingtai,Hebei,China,054000;Department of Clinical Laboratory,Xingtai Central Hospital,Xingtai,Hebei,China,054000)

机构地区：[1]邢台市中心医院心内科,河北邢台054000 [2]邢台市中心医院检验科,河北邢台054000

出　　处：《分子诊断与治疗杂志》2024年第12期2270-2273,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究课题计划(20191677)。

摘　　要：目的探讨血清淀粉样蛋白A(SAA)、尿白蛋白与肌酐比值(ACR)及动脉硬化指数(AASI)检测在高血压早期肾损害中的预测价值及临床意义。方法选取2021年5月至2023年5月邢台市中心医院收治的57例单纯高血压者为对照组,59例发生肾损害的高血压者为观察组,对比两组一般资料、SAA、ACR水平及AASI值,分析影响高血压患者出现肾损害的相关因素,评估SAA、ACR及AASI对高血压患者出现肾损害的预测价值。结果两组性别、年龄、糖尿病、吸烟、体质指数、空腹血糖等比较,差异无统计学意义(P>0.05);两组高血压分级、尿酸(UA)水平比较,差异有统计学意义(P<0.05)。观察组SAA、ACR水平及AASI值均明显高于对照组,差异有统计学意义(P<0.05)。logistic多因素分析显示:高血压分级3级、UA>410μmol/L、SAA>10 mg/L、ACR>30 mg及AASI<4是高血压患者出现早期肾损害的相关影响因素(P<0.05)。ROC结果显示,SAA、ACR及AASI联合预测高血压患者出现早期肾损害的AUC为0.894,高于三指标单独检测(P<0.05)。结论SAA、ACR及AASI检测在预测高血压出现早期肾损害中具有重要临床意义,且三指标联合预测高血压早期肾损害的准确性更高,可为临床诊断及治疗提供可靠的参考资料。Objective To investigate the predictive value and clinical significance of serum amyloid A(SAA),urinary albumin to creatinine ratio(ACR)and arteriosclerosis index(AASI)in early renal damage in hypertension.Methods A total of 57 patients with uncomplicated hypertension admitted to Xingtai Central Hospital from May 2021 to May 2023 were selected as the control group,while 59 patients with hyper⁃tension and kidney damage were chosen as the observation group.The general data,SAA,ACR levels and AASI values of both groups were compared.Factors affecting renal damage in patients with hypertension were analyzed,and the predictive value of SAA,ACR,and AASI for renal damage in patients with hypertension was evaluated.Results The gender,age,presence of diabetes mellitus,smoking habits,body mass index,and fasting blood glucose levels between the two groups showed no statistically significant difference(P>0.05).However,there were statistically significant differences in hypertension grading and uric acid(UA)lev⁃els between the two groups(P<0.05).The SAA,ACR levels,and AASI values in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Logistic multivariate analysis showed that hypertension grade 3,UA>410μmol/L,SAA>10 mg/L,ACR>30 mg and AASI<4 were related factors to early renal damage in patients with hypertension(P<0.05).The ROC results showed that the AUC of SAA,ACR,and AASI in predicting early renal damage in patients with hypertension was 0.894,which was higher than that of each individual index alone(P<0.05).Conclusion The detection of SAA,ACR,and AASI has important clinical significance in predicting early renal damage in hypertension.The combination of the three indicators has higher accuracy in predicting early renal damage in hypertension,providing a reliable reference for clinical diagnosis and treatment.

关 键 词：SAA ACR 动脉硬化指数 高血压 肾损害 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]