血清25⁃(OH)D、miR⁃26a、CTRP3水平与2型DM患者CIMT及CVD风险的相关性  

Correlation of serum 25⁃(OH)D,miR⁃26a,and CTRP3 levels with CIMT and CVD risk in patients with type 2 DM

作　　者：张玲霞 彭婷瑜 周纽纽 张玲燕 蔡潇潇 ZHANG Lingxia;PENG Tingyu;ZHOU Niuniu;ZHANG Lingyan;CAI Xiaoxiao(Department of Endocrinology,the Sixth People's Hospital of Nantong,Nantong,Jiangsu,China,226001)

机构地区：[1]南通市第六人民医院内分泌科,江苏南通226001

出　　处：《分子诊断与治疗杂志》2024年第12期2278-2281,共4页Journal of Molecular Diagnostics and Therapy

基　　金：江苏省科技厅基础研究计划项目(BK20201077)。

摘　　要：目的探究血清25⁃羟基维生素D(25⁃(OH)D)、微小RNA(miR)⁃26a、补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)水平与2型糖尿病患者颈动脉内膜中层厚度(CIMT)及心血管疾病(CVD)风险的相关性。方法选取2022年6月至2024年6月期间南通市第六人民医院收治的112例2型糖尿病患者作为研究对象,根据心血管疾病风险等级分为低风险组(28例)、中风险组(39例)和高风险组(45例)。比较3组间血清25⁃(OH)D、miR⁃26a和CTRP3水平的差异,采用斯皮尔曼相关性分析及多元logistics回归分析以上指标与2型糖尿病患者CIMT和CVD风险的相关性。结果3组性别相比较,差异无统计学意义(P>0.05)。3组的年龄和CIMT比较结果:低风险组<中风险组<高风险组,差异有统计学意义(P<0.05)。血清25⁃(OH)D、miR⁃26a和CTRP3水平比较:低风险组>中风险组>高风险组,差异有统计学意义(P<0.05)。斯皮尔曼相关性分析和多元logistics回归分析结果显示,血清25⁃(OH)D、miR⁃26a和CTRP3水平均与2型糖尿病患者CIMT和CVD风险成负相关,差异具有统计学意义(P<0.05)。结论血清25⁃(OH)D、miR⁃26a和CTRP3水平与2型糖尿病患者CIMT和CVD风险具有一定的相关性,可作为临床提示2型糖尿病患者发生心血管疾病的辅助指标。O4bjective To investigate the correlation between serum 25⁃hydroxy vitamin D(25⁃(OH)D),microRNA(miR)⁃26a,and complement C1q/tumor necrosis factor⁃related protein 3(CTRP3)levels and carotid intima⁃media thickness(CIMT)and cardiovascular disease(CVD)risk in patients with type 2 diabetes.Methods A total of 112 patients with type 2 diabetes admitted to the Sixth People's Hospital of Nantong between June 2022 and June 2024 were selected as the study subjects.They were divided into three groups based on their risk class of cardiovascular disease:a low⁃risk group(28 patients),an intermediate⁃risk group(39 patients),and a high⁃risk group(45 patients).Differences in serum 25⁃(OH)D,miR⁃26a,and CTRP3 levels were compared among the 3 groups.The correlation between the above indicators and the risk of CIMT and CVD in patients with type 2 diabetes mellitus was analyzed using Spearman correlation analysis and multivariate logistic regression.Results Compared to the gender of the 3 groups,the difference was not statisti⁃cally significant(P>0.05).when comparing the age and CIMT in the 3 groups,there was a statistically significant difference,with the low⁃risk group<intermediate⁃risk group<high⁃risk group(P<0.05).The comparison of serum 25⁃(OH)D,miR⁃26a,and CTRP3 levels among the 3 groups showed that the low⁃risk group>inter⁃mediate⁃risk group>high⁃risk group,and the differences were statistically significant(P<0.05).The results of Spearman correlation analysis and multivariate logistic regression analysis indicated that serum 25⁃(OH)D,miR⁃26a,and CTRP3 levels were all negatively correlated with the risk of CIMT and CVD in patients with type 2 diabetes mellitus,and the differences were statistically significant(P<0.05).Conclusion Serum 25⁃(OH)D,miR⁃26a,and CTRP3 levels are correlated with CIMT and CVD risk in patients with type 2 diabetes mellitus.They can be used as auxiliary indicators to clinically suggest the occurrence of cardiovascular disease in patients with type 2 diabetes m

关 键 词：25⁃羟基维生素D 微小RNA⁃26a 补体C1q/肿瘤坏死因子相关蛋白3 2型糖尿病 颈动脉内膜中层厚度 心血管疾病 

分 类 号：R587.2[医药卫生—内分泌] R54[医药卫生—内科学]