VCAM⁃1、BMP⁃2及IL⁃6水平变化与儿童尺桡骨骨折延长愈合的关系  

Relationship between the changes of VCAM⁃1,BMP⁃2 and IL⁃6 levels and the prolonged healing of ulna and radius fractures in children

作　　者：雷贞 魏峥 常丹芍 孙克明 胡玲玲 LEI Zhen;WEI Zheng;CHANG Danshao;SUN Keming;HU Lingling(Department of Orthopedics,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,Henan,China,450018;Department of Anesthesia and Perioperative Medicine,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,Henan,China,450018)

机构地区：[1]河南省儿童医院郑州儿童医院骨科,河南郑州450018 [2]河南省儿童医院郑州儿童医院麻醉与围手术期医学科,河南郑州450018

出　　处：《分子诊断与治疗杂志》2024年第12期2351-2354,2359,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20220714)。

摘　　要：目的探讨血清中血管细胞黏附分子⁃1(VCAM⁃1)、骨形态发生蛋白2(BMP⁃2)和白介素⁃6(IL⁃6)水平的变化与儿童尺桡骨骨折延长愈合之间的关系。方法选取2020年5月至2023年7月河南省儿童医院郑州儿童医院收治的共计152例儿童尺桡骨骨折的患儿作为研究对象。按照骨折愈合情况分为对照组(正常愈合)、观察组(未正常愈合)。比较两组一般资料、骨折后1周、术后4周、术后8周、术后1个月、术后4个月及术后6个月血清中VCAM⁃1、BMP⁃2和IL⁃6水平变化;绘制ROC曲线评估VCAM⁃1、BMP⁃2及IL⁃6单一及联合检测对儿童尺桡骨骨折延长愈合的预测价值。结果两组性别、年龄、骨折类型及受伤原因比较,差异无统计学意义(P>0.05)。两组骨折后1周VCAM⁃1、BMP⁃2及IL⁃6水平比较,差异无统计学意义(P>0.05);两组术后4周、8周、1个月、4个月及6个月比较,观察组VCAM⁃1及IL⁃6水平更高,BMP⁃2水平更低,差异有统计学意义(P<0.05)。依据ROC曲线可知,VCAM⁃1、BMP⁃2及IL⁃6联合检测儿童尺桡骨骨折延长愈合的灵敏度、特异度分别为91.22%、86.73%,AUC为0.915,高于单一检测(P<0.05)。结论血清VCAM⁃1、BMP⁃2及IL⁃6水平与儿童尺桡骨骨折延长愈合紧密相关,三指标联合检测有望成为有效监测手段,帮助医生掌握愈合进展,调整治疗,促进骨折顺利愈合。Objective To investigate the relationship between the changes of serum vascular cell adhesion molecule⁃1(VCAM⁃1),bone morphogenetic protein⁃2(BMP⁃2)and interleukin⁃6(IL⁃6)levels and the prolonged healing of ulna and radius fractures in children.Methods A total of 152 children with ulna and radius fractures admitted to Zhengzhou Childrens Hospital of Henan Childrens Hospital from May 2020 to July 2023 were selected as the research subjects.Based on the fracture healing progress,they were divided into two groups:a control group with normal healing and an observation group with abnormal healing.The levels of VCAM⁃1,BMP⁃2,and IL⁃6 in serum were compared between the two groups at 1 week,4 weeks,8 weeks,1 month,4 months,and 6 months after the fracture occurred.An ROC curve was constructed to assess the predictive value of single and combined detection of VCAM⁃1,BMP⁃2,and IL⁃6 in predicting prolonged healing of ulnar and radial fractures in children.Results There was no significant difference in gender,age,fracture type and cause of injury between the two groups(P>0.05).There was no significant difference in the levels of VCAM⁃1,BMP⁃2,and IL⁃6 between the two groups at 1 week after fracture(P>0.05).When com⁃paring the two groups at 4 weeks,8 weeks,1 month,4 months,and 6 months after the operation,the levels of VCAM⁃1 and IL⁃6 in the observation group were higher,and the level of BMP⁃2 was lower,the difference was statistically significant(P<0.05).According to the ROC curve,the sensitivity and specificity of the com⁃bined detection of VCAM⁃1,BMP⁃2,and IL⁃6 in the prolonged healing of ulnar and radial fractures in chil⁃dren were 91.22%and 86.73%,respectively,and AUC:0.915,which was significantly higher than that of single detection(P<0.05).Conclusion The levels of serum VCAM⁃1,BMP⁃2,and IL⁃6 are closely related to the prolonged healing of ulna and radius fractures in children.The combined detection of these three indica⁃tors is expected to become an effective monitor

关 键 词：血管细胞黏附分子⁃1 骨形态发生蛋白2 白介素⁃6 尺桡骨骨折 延长愈合 

分 类 号：R726.8[医药卫生—儿科]