血清VitA、25(OH)D及IgE检测在儿童支气管哮喘临床诊疗中的意义  

The significance of serum Vitamin A,25⁃hydroxyvitamin D,and IgE detection in the clini⁃cal diagnosis and treatment of pediatric bronchial asthma

作　　者：马俊娥 李东 王未 张倩倩 毕颖薇 MA June;LI Dong;WANG Wei;ZHANG Qianqian;BI Yingwei(Department of Pediatrics,Civil Aviation General Hospital,Beijing,China,100123;Department of Clinical Laboratory,Civil Aviation General Hospital,Beijing,China,100123)

机构地区：[1]民航总医院儿科,北京朝阳100123 [2]民航总医院检验科,北京朝阳100123

出　　处：《分子诊断与治疗杂志》2024年第12期2364-2367,2372,共5页Journal of Molecular Diagnostics and Therapy

基　　金：民航医学中心(民航总医院)科研项目(202218)。

摘　　要：目的探讨血清维生素A(VitA)、25⁃羟维生素D[(25(OH)D)]及免疫球蛋白E(IgE)检测在儿童支气管哮喘临床诊疗中的意义。方法本研究为回顾性分析,根据纳入和排除标准筛选了2021年10月至2023年2月于民航总医院儿童呼吸过敏门诊诊治的131例支气管哮喘患儿作为观察组;同时选取同期于本院体检的129名健康儿童作为对照组。比较对照组和观察组、观察组中不同哮喘病情严重程度患儿血清VitA、25(OH)D及IgE水平;根据哮喘控制测试评估将131例支气管哮喘患儿分为良好控制组、部分控制组和未控制组,对比三组临床资料(年龄、性别、运动情况、过敏史及哮喘病情严重程度等)和实验室指标(血清VitA、25(OH)D及IgE水平);采用多元有序Logistic回归模型分析影响支气管哮喘控制水平的相关因素。结果观察组血清VitA、25(OH)D水平低于对照组,IgE水平高于对照组,差异有统计学意义(P<0.05)。三组VitA、25(OH)D水平比较:轻度哮喘>中度哮喘>重度哮喘,三组IgE水平比较:重度哮喘>中度哮喘>轻度哮喘,差异有统计学意义(P<0.05)。131例支气管哮喘患儿中,良好控制36例、部分控制53例、未控制组42例,三组年龄、性别、运动、过敏史比较差异无统计学意义(P>0.05),三组病情严重程度及VitA、25(OH)D及IgE水平比较差异有统计学意义(P<0.05)。多元有序Logistics回归分析结果表明,在以儿童哮喘的控制水平为因变量时,病情严重程度为重度、血清VitA降低、25(OH)D降低及IgE水平升高是影响儿童哮喘控制水平的独立危险因素(P<0.05)。结论血清VitA、25(OH)D及IgE检测三指标水平有助于临床评估病情严重程度,可为制定个体化治疗方案和判断疾病进展提供参考依据。Objective To investigate the significance of serum vitamin A(VitA),25⁃hydroxyvi⁃tamin D(25(OH)D)and immunoglobulin E(IgE)in the clinical diagnosis and treatment of bronchial asthma in children.Methods This study involved a retrospective analysis.Based on the inclusion and exclusion criteria,131 children with bronchial asthma who received treatment at the Childrens Respiratory Allergy Clinic of Civil Aviation General Hospital from October 2021 to February 2023 were selected as the observation group.Meanwhile,129 healthy children who underwent physical examinations at our hospital during the same period were chosen as the control group.The serum VitA,25(OH)D and IgE levels of children with different sever⁃ity of asthma were compared between the control group and the observation group.Based on the assessment of asthma control test,131 children with bronchial asthma were divided into a good control group,a partial control group and an uncontrolled group.Clinical data(such as age,sex,exercise,allergy history and severity of asthma)and laboratory indicators(serum VitA,25(OH)D and IgE levels)of the three groups were com⁃pared.A multiple ordered logistic regression model was used to analyze the related factors affecting the control level of bronchial asthma.Results The levels of serum VitA and 25(OH)D in the observation group were lower than those in the control group,and the IgE level was higher than that in the control group,the differ⁃ences were statistically significant(P<0.05).VitA and 25(OH)D levels were compared among the three groups:mild asthma>moderate asthma>severe asthma;IgE levels were compared among the three groups:severe asthma>moderate asthma>mild asthma,and the difference was statistically significant(P<0.05).Out of the 131 children with bronchial asthma,36 cases were well controlled,53 cases were partially controlled,and 42 cases were not controlled.There were no statistically significant differences in age,gender,exercise,and allergy history among the three groups(P>0.05).However,there were

关 键 词：维生素A 25⁃羟维生素D 免疫球蛋白E 支气管哮喘 

分 类 号：R725.6[医药卫生—儿科]