孕早期血清CTRP家族分子的水平预测妊娠期糖尿病的价值分析  

Analysis of the value of serum CTRP family molecules in the first trimester in predicting gestational diabetes mellitus

作　　者：高霞[1] 郭燕[1] 高燕芳 GAO Xia;GUO Yan;GAO Yanfang(Obstetrics and Gynecology Department of Heping Hospital Affiliated to Changzhi Medical College,Changzhi,Shanxi046000)

机构地区：[1]长治医学院附属和平医院妇产科,山西长治046000

出　　处：《分子诊断与治疗杂志》2024年第12期2390-2393,共4页Journal of Molecular Diagnostics and Therapy

基　　金：山西省卫健委科研项目(20220139)。

摘　　要：目的研究孕早期血清补体C1q/肿瘤坏死因子相关蛋白(CTRP)家族分子的水平在预测妊娠期糖尿病(GDM)中的价值。方法选择2022年6月至2024年3月期间在进行产检的孕妇,收集孕早期(妊娠6~14周)的临床资料及血清,检测CTRP3、CTRP5、CTRP6、CTRP9、CTRP12水平。根据孕中期(妊娠24⁃28周)的口服葡萄糖耐量试验结果,将入组孕妇分为符合GDM诊断的GDM组(n=42)和糖耐量正常的对照组(n=162),比较两组孕妇临床资料及血清指标的差异,采用logistic回归模型分析GDM的影响因素,采用ROC曲线分析GDM的预测指标。结果GDM组的年龄、孕前体质量指数(BMI)以及孕早期空腹血糖(FBG)、空腹胰岛素、糖化血红蛋白A1c(HbA1c)、血清CTRP5、CTRP6水平均高于对照组,差异有统计学意义(P<0.05),CTRP3、CTRP9、CTRP12低于对照组,差异有统计学意义(P<0.05);logistic回归分析显示:孕前BMI以及孕早期FBG、HbA1c、CTRP3、CTRP5、CTRP6、CTRP9、CTRP12是发生GDM的影响因素(P<0.05);ROC曲线分析显示:CTRP3、CTRP5、CTRP6、CTRP9、CTRP12单独以及与各影响因素联合预测的曲线下面积分别为0.792、0.808、0.796、0.784、0.761、0.902(P<0.05)。结论孕早期血清CTRP3、CTRP5、CTRP6、CTRP9、CTRP12水平对GDM具有一定的预测价值。Objective To study the value of serum complement⁃C1q/tumor necrosis factor⁃related protein(CTRP)family molecules in the first trimester in predicting gestational diabetes mellitus(GDM).Methods Pregnant women who were undergoing antenatal check⁃up from June 2022 to March 2024 were selected,and clinical data and serum in the first trimester(6⁃14 weeks of gestation)were collected,the levels of CTRP3,CTRP5,CTRP6,CTRP9 and CTRP12 were detected.According to the results of oral glucose tolerance test in the second trimester(24⁃28 weeks of gestation),the enrolled pregnant women were divided into GDM group(n=42)which met the diagnosis of GDM and control group(n=162)which had normal glucose tolerance.The differences of clinical data and serum indexes between the two groups were compared,and the influencing factors of GDM were analyzed by logistic regression model.ROC curve was used to analyze the predictive indexes of GDM.Results The levels of age,pre⁃pregnancy body mass index(BMI),fasting blood glucose(FBG),fasting insulin,glycated hemoglobin A1c(HbA1c),serum CTRP5 and CTRP6 in GDM group were higher than those in control group,the difference was statistically significant(P<0.05),while CTRP3,CTRP9 and CTRP12 were lower than the control group,the difference was statistically signifi⁃cant(P<0.05).Logistic regression analysis showed that pre⁃pregnancy BMI and FBG,HbA1c,CTRP3,CTRP5,CTRP6,CTRP9,CTRP12 in the first trimester were the influencing factors for GDM(P<0.05).ROC curve analysis showed that the areas under the curve predicted by CTRP3,CTRP5,CTRP6,CTRP9 and CTRP12 alone and in combination with other influencing factors were 0.792,0.808,0.796,0.784,0.761 and 0.902,respectively(P<0.05).Conclusion Serum levels of CTRP3,CTRP5,CTRP6,CTRP9 and CTRP12 in early pregnancy have predictive value for GDM.

关 键 词：妊娠期糖尿病 补体C1q/肿瘤坏死因子相关蛋白 孕早期 

分 类 号：R714.256[医药卫生—妇产科学]