乳化交联法制备生物相容性高分子载药微球  

Preparation of biocompatible drug-loaded microspheres by emulsion crosslinking

作　　者：李嘉炜 秦仟皓 赵胜博 李宁[1] 王耀宗 黄潇楠[1] LI Jiawei;QIN Qianhao;ZHAO Shengbo;LI Ning;WANG Yaozong;HUANG Xiaonan(Department of Chemistry,Capital Normal University,Beijing 100048;Beijing Education Examinations Authority,Beijing 100083)

机构地区：[1]首都师范大学化学系,北京100048 [2]北京教育考试院,北京100083

出　　处：《首都师范大学学报（自然科学版）》2024年第6期30-35,共6页Journal of Capital Normal University：Natural Science Edition

基　　金：首都师范大学青年卓越人才培养计划项目。

摘　　要：为了解决高分子载药微球尺寸不均一、制备方法难等问题,使其更好地应用于肿瘤治疗、软骨修复等临床领域。本文以聚乙烯醇、明胶和海藻酸钠为原料,通过自由基聚合、席夫碱反应和钙离子配位反应共3种乳化交联法制备高分子载药微球,并载药阿霉素盐酸盐。利用红外光谱仪、扫描电子显微镜和紫外-可见分光光度计等仪器对其进行表征。结果表明,本文所制备的3种载药微球尺寸均一,材料易降解,且能够满足癌症治疗中的释药需求。In order to solve the problems of uneven size and difficult preparation methods of drug-loaded microspheres,and to better apply them in clinical fields such as tumor treatment and cartilage repair.In this paper,drug-loaded polymer microspheres were prepared from polyvinyl alcohol,gelatin and sodium alginate by free radical polymerization,Schiff base reaction and calcium ion coordination reaction.It was characterized using instruments such as infrared spectroscopy,scanning electron microscopy,and ultraviolet-visible spectrophotometer.The results indicate that the three drug-loaded microspheres prepared in this article have uniform size,easy degradation of materials,and can meet the drug release requirements in cancer treatment.

关 键 词：高分子 载药微球 乳化交联法 药物缓释 

分 类 号：O6-3[理学—化学]