覆膜支架腔内修复术对Stanford B型主动脉夹层患者肝肾功能及炎症因子的影响  

The Impact of Endovascular Repair with covered stent on Liver and Kidney Function and Inflammatory Factors in Patients with Stanford Type B Aortic Dissection

作　　者：王鹏飞 陈宁 马培尧 孔深柯 王鑫 曹占伟 WANG Pengfei;CHEN Ning;MA Peiyao;KONG Shenke;WANG Xin;CAO Zhanwei(Department of Cardiology,Henan Chest Hospital(Affiliated Chest Hospital of Zhengzhou University),Zhengzhou Henan 450000,China)

机构地区：[1]河南省胸科医院(郑州大学附属胸科医院)心内科,河南郑州450000

出　　处：《临床研究》2025年第1期9-11,共3页Clinical Research

摘　　要：目的探讨Stanford B型主动脉夹层患者接受将覆膜支架腔内修复术治疗的临床效果。方法本研究共纳入2021年10月至2023年10月河南省胸科医院收治的110例Stanford B型主动脉夹层患者,将所有患者根据随机数字表法分为对照组(55例,接受药物保守治疗)和研究组(55例,采用覆膜支架腔内修复术治疗)。比较两组患者治疗前、治疗2周后肝肾功能指标、血清炎症因子相关指标,以及两组患者病死率、并发症发生情况。结果治疗2周后,研究组患者丙氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、血尿素氮(BUN)、肌酐(Cr)指标水平相较于治疗前均有所降低,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗2周后,研究组患者血清炎症因子指标肿瘤坏死因子-α(TNF-α)、白细胞介素(IL-1β)、干扰素-γ(IFN-γ)、C-反应蛋白(CRP)相较于治疗前均有所降低,且研究组低于对照组,差异有统计学意义(P<0.05)。两组患者病死率、再次手术或介入率比较,差异无统计学意义(P>0.05)。研究组患者并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论Stanford B型主动脉夹层患者接受覆膜支架腔内修复术治疗,可对肝肾功能起到改善作用,减轻炎症反应,安全性较高,值得临床应用。Objective To explore the clinical effects of endovascular repair with covered stent in patients with Stanford type B aortic dissection.Methods This study included 110 patients with Stanford type B aortic dissection admitted to Henan Chest Hospital from October 2021 to October 2023.All patients were randomly divided into a control group(55 cases receiving medical conservative treatment)and a study group(55 cases treated with endovascular repair using covered stent).The liver and kidney function indicators,serum inflammatory factor levels,mortality rates,and incidence of complications were compared between the two groups before treatment and 2 weeks after treatment.Results After 2 weeks of treatment,the study group showed a significant reduction in alanine transaminase(ALT),aspartate transaminase(AST),blood urea nitrogen(BUN),and creatinine(Cr)levels compared to baseline,with these levels also being significantly lower than those in the control group(P<0.05).Similarly,after 2 weeks,levels of serum inflammatory factors,including tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),interferon-gamma(IFN-γ),and C-reactive protein(CRP),decreased in the study group compared to baseline,and these levels were significantly lower than those in the control group(P<0.05).There were no significant differences in mortality rates and reoperation or intervention rates between the two groups(P>0.05).However,the incidence of complications in the study group was significantly lower than that in the control group(P<0.05).Conclusion Endovascular repair with covered stent in patients with Stanford type B aortic dissection can improve liver and kidney function,reduce inflammatory responses,and has a high safety profile,making it valuable for clinical application.

关 键 词：覆膜支架腔内修复术 Stanford B型主动脉夹层 肝肾功能 炎症因子 影响 

分 类 号：R543.1[医药卫生—心血管疾病]