CKM_(Bmass)、PTX-3对STEMI预后和急诊PCI后不良事件的预测  

The Predictive Value of CKM_(Bmass) and PTX-3 Levels for Prognosis and Adverse Events After Emergency PCI in STEMI Patients

作　　者：袁晓青 YUAN Xiaoqing(Department of Cardiology,Second People's Hospital of Neihuang County,Neihuang Henan 456300,China)

机构地区：[1]内黄县第二人民医院心内科,河南内黄456300

出　　处：《临床研究》2025年第1期36-40,共5页Clinical Research

摘　　要：目的探讨肌酸激酶心型同工酶质量(CKM_(Bmass))、正五聚蛋白3(PTX-3)水平对急性ST段抬高型心肌梗死(STEMI)预后以及经皮冠状动脉介入手术(PCI)后不良事件的预测价值。方法选取2021年1月至2023年5月内黄县第二人民医院收治的80例STEMI患者,所有患者均进行PCI手术,记录患者此期间内出现恶性心律失常、非致死性心肌梗死或者心力衰竭等不良心血管事件(MACE)的发生情况,其中40例出现不良事件为MACE组,40例康复正常为无MACE组,比较两组一般资料、血脂、血清水平,并进行分析。结果两组患者的性别、BMI以及基础病史差异无统计学意义(P>0.05),MACE组的年龄、吸烟比例均明显高于无MACE组,差异有统计学意义(P<0.05);MACE组低密度脂蛋白胆固醇、三酰甘油水平明显高于无MACE组,高密度脂蛋白胆固醇明显低于无MACE组,差异有统计学意义(P<0.05);MACE组CKM_(Bmass)、PTX-3水平均明显高于无MACE组,差异有统计学意义(P<0.05);Logistic分析结果表明,CKM_(Bmass)、PTX-3为STEMI患者预后的独立影响因素(P<0.05);受试者工作曲线(ROC)诊断结果表明,CKM_(Bmass)、PTX-3对STEMI预后不良事件的诊断价值较高,曲线下面积(AUC)分别为0.772、0.895,联合诊断的价值最高,AUC为0.926。结论使用CKM_(Bmass)、PTX-3水平联合诊断STEMI预后及急诊PCI后不良事件效能较高,值得应用。Objective To investigate the predictive value of creatine kinase myocardial band mass(CKM_(Bmass))and pentraxin-3(PTX-3)levels for the prognosis of patients with acute ST-segment elevation myocardial infarction(STEMI)and for adverse events following percutaneous coronary intervention(PCI).Methods A total of 80 STEMI patients who underwent PCI at the Second People's Hospital of Neihuang County from January 2021 to May 2023 were enrolled in this study.The incidence of major adverse cardiovascular events(MACE),including malignant arrhythmias,non-fatal myocardial infarctions,or heart failure,was recorded.Among them,40 patients experienced adverse events and were classified into the MACE group,while 40 patients who recovered normally were classified as the non-MACE group.General information,lipid profiles,and serum levels were compared and analyzed between the two groups.Results There were no statistically significant differences in gender,BMI,or medical history between the two groups(P>0.05).The MACE group had significantly higher age and smoking rates compared to the non-MACE group,and the difference was statistically significant(P<0.05);The levels of low-density lipoprotein cholesterol and triglyceride levels in the MACE group were significantly higher than those in the non-MACE group,while high-density lipoprotein cholesterol(HDL-C)levels were significantly lower in the MACE group(P<0.05).The CKM_(Bmass) and PTX-3 levels were also significantly higher in the MACE group compared to the non-MACE group(P<0.05).Logistic regression analysis indicated that CKM_(Bmass) and PTX-3 levels were independent predictors of poor prognosis in STEMI patients(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that CKM_(Bmass) and PTX-3 had high diagnostic value for predicting poor outcomes in STEMI,with area under the curve(AUC)values of 0.772 and 0.895,respectively.The combined diagnostic value yielded the highest AUC of 0.926.Conclusion Combined assessment of CKM_(Bmass) and PTX-3 levels is highly effective for p

关 键 词：STEMI 不良事件 CKM_(Bmass) 

分 类 号：R542.22[医药卫生—心血管疾病]