中医“正气存内,邪不可干”与机体内源性抗损伤反应的相关性初探  

A Preliminary study on the correlation between traditional Chinese medicine’s“Keeping healthy Qi and preventing evil pathogens”and the body’s endogenous anti-injury response

作　　者：徐世红[1] 赵军[1] 王兴盛[1] 王培鑫 姜朝阳 王小强 

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃中医药大学,甘肃兰州730000

出　　处：《中医临床研究》2024年第27期144-148,共5页Clinical Journal Of Chinese Medicine

基　　金：基于网络药理学平台逆向筛选中药组方干预骨折中期愈合的实验研究(2020-RC-55);基于网络药理学探讨“接骨续筋”富集方药作用骨折中期药效学及作用机制研究(GZKZ-2021-4);甘肃省骨科创伤临床研究中心(21JR7RA681);甘肃省第四批五级中医药师承教育项目。

摘　　要：内源性抗损伤反应是生物机体清除体内细菌病毒、维持机体内环境稳态的重要自我保护机制。其通过诱导相关保护蛋白,使机体自身防御系统产生对抗损伤的触发物质和中介物质,从而激活金属硫蛋白、热休克蛋白、一氧化氮、丝裂素活化蛋白激酶等效应物质及相关信号通路,提高机体对疾病的适应能力与抗损伤能力,是防治疾病、维持机体自身稳态的重要途径。中医“正气存内,邪不可干”理论是对人体发挥抗病、祛邪、调节、修复功能和机体对外界刺激适应能力的高度概括,阐明了在疾病的发生发展过程中正气发挥着主导作用,正气不足是疾病发生的先决条件。而且正气发挥正常的生理功能要满足“足”“通”“和”三个基本条件。内源性抗损伤反应与中医“正气存内,邪不可干”理论联系密切,都表明了正气不足、抵抗力下降是机体发病的前提条件,正气与抗损伤物质不能通达患病部位是机体发病的重要原因。本研究基于中医“正气存内,邪不可干”理论与机体内源性抗损伤反应的防治特点、防治通路及物质基础等为契入点,研究机体内源性抗损伤反应与中医“正气存内,邪不可干”理论的相关性,揭示其在疾病预防和诊疗过程中的重要作用。Endogenous anti-injury response is an important self-protection mechanism for the organism to eliminate bacteria and Eviruses in the body and maintain the homeostasis of the organism.By inducing related protective proteins,it makes the body’s own defense system produce trigger substances and intermediary substances to fight damage,thereby activating effector substanc-es such as metallothionein,heat shock protein,nitric oxide,mitotin-activated protein kinase and related signaling pathways,improving the body’s ability to adapt to diseases and resist damage,which is an important way to prevent and control diseases and maintain the body’s homeostasis.The traditional Chinese medicine theory of“Keeping healthy Qi(气)and preventing evil pathogens”is a high generaliza-tion of the human body to play the function of disease resistance,exorcism,regulation,repair and the body’s ability to adapt to external stimuli,clarifying that healthy Qi plays a leading role in the occurrence and development of diseases,and the deficiency of healthy Qi is a prerequisite for the occurrence of diseases.And the normal physiological function of positive Qi should meet the three basic conditions of“sufficiency”,“passibility”and“harmony”.Endogenous anti-injury response is closely related to the theory of traditional Chinese medicine“Keeping healthy Qi and preventing evil pathogens”,which indicates that the deficiency of healthy Qi and the decline of resistance are the preconditions for the disease of the body,and the important reason for the disease is that healthy Qi and anti-injury substances cannot reach the diseased site.Based on the TCM theory of“Keeping healthy Qi and preventing evil pathogens”and the prevention and control charac-teristics,prevention and control pathways and material basis of the body’s endogenous anti-injury response,this paper studies the correla-tion between the body’s endogenous anti-injury response and the TCM theory of“Keeping healthy Qi and preventing evil pathogens”,and re

关 键 词：内源性抗损伤反应 正气存内 邪不可干 抗损伤物质 

分 类 号：R4[医药卫生—临床医学]