丹红注射液治疗急性ST段抬高型心肌梗死早期左心室室壁瘤的效果  

The Effect of Danhong Injection in the Treatment of Early Left Ventricular Aneurysm in Acute ST-Segment Elevation Myocardial Infarction

作　　者：李芳[1] LI Fang(Department of Cardiology,the Second People’s Hospital of Jiyuan City,Jiyuan 459000,China)

机构地区：[1]济源市第二人民医院心内科,河南济源459000

出　　处：《实用临床医学（江西）》2024年第6期12-15,58,共5页Practical Clinical Medicine

摘　　要：目的探讨丹红注射液治疗急性ST段抬高型心肌梗死早期左心室室壁瘤的效果。方法将100例急性ST段抬高型心肌梗死早期左心室室壁瘤患者随机分为对照组与观察组,每组50例。对照组行经皮冠状动脉介入术(PCI)治疗,观察组在对照组治疗基础上给予丹红注射液治疗。比较2组治疗前后左心功能[左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期内径(LVDEd)]、血流动力学指标[平均二尖瓣压力差(mMPG)、平均肺动脉压(mPAP)]的改善情况及术后6个月生存率、心肌梗死早期左心室室壁瘤复发率,观察2组术后1个月心脏事件发生情况。结果2组术后14 d LVESV、LVEF、LVDEd、mPAP、mMPG值均较术前明显改善,且观察组改善程度明显优于对照组,差异均有统计学意义(P<0.05)。观察组术后1个月心脏事件总发生率为4.00%,显著低于对照组的18.00%(P<0.05)。2组术后6个月心肌梗死早期左心室室壁瘤复发率、生存率比较差异无统计学意义(P>0.05)。结论丹红注射液治疗ST段抬高型心肌梗死早期左心室室壁瘤患者能减少术后心脏事件的发生,促进术后恢复。Objective To investigate the effects of Danhong injection in the treatment of early left ventricular aneurysm in patients with acute ST-segment elevation myocardial infarction.Methods A total of 100 patients with early left ventricular aneurysm due to acute ST-segment elevation myocardial infarction were randomly divided into a control group and an observation group,with 50 patients in each group.The control group underwent percutaneous coronary intervention(PCI),while the observation group received Danhong injection therapy on the basis of the control group’s treatment.The improvement of left ventricular function[including left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),and left ventricular enddiastolic diameter(LVDEd)]and hemodynamic indexes[mean mitral valve pressure gradient(mMPG)and mean pulmonary artery pressure(mPAP)]before and after treatment were compared between the 2 groups;the 6-month survival rate,recurrence rate of early left ventricular aneurysm after myocardial infarction,and the occurrence of cardiac events at 1 month postoperatively were observed in both groups.Results The values of LVESV,LVEF,LVDEd,mPAP,and mMPG in both groups at 14 days postoperatively were significantly improved compared to those before surgery,and the degree of improvement in the observation group was significantly better than that in the control group,with statistically significant differences(P<0.05).The total incidence of cardiac events at 1 month postoperatively in the observation group was 4.00%,which was significantly lower than that in the control group(18.00%)(P<0.05).There were no statistically significant differences in the recurrence rate of early left ventricular aneurysm after myocardial infarction and the survival rate at 6 months postoperatively between the 2 groups(P>0.05).Conclusion This study suggests that Danhong injection can reduce the occurrence of postoperative cardiac events and promote postoperative recovery in patients with early left ventricular aneurysm due t

关 键 词：丹红注射液 急性ST段抬高型心肌梗死 左心室室壁瘤 经皮冠状动脉介入术 左心室血栓 

分 类 号：R541.4[医药卫生—心血管疾病]