2型糖尿病患者心电图PR、QT、QTc间期延长与颈动脉粥样硬化相关性研究  

Correlation between prolonged ECG PR,QT,QTcintervals and carotid atherosclerosis in T2DM patients

作　　者：李丽丽 杨敏 LI Lili;YANG Min(Department of Electrophysiology,Xi’an People’s Hospital,Xi’an 710004,China)

机构地区：[1]西安市人民医院心电生理科,陕西西安710004

出　　处：《陕西医学杂志》2025年第1期71-75,共5页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(2017ZDCXL-SF-02-04-02)。

摘　　要：目的:探讨心电图PR、QT、QTc间期延长与2型糖尿病(T2DM)患者发生颈动脉粥样硬化的关系。方法:采用病例对照研究方法,选取97例确诊为T2DM且伴有颈动脉粥样硬化(CAS)的患者作为CAS组,选取确诊为T2DM但颈动脉未发现粥样硬化的95例患者作为对照组,比较两组患者的心电图PR、QT、QTc间期测定值、血糖血脂等,采用多因素分析方法探讨心电图PR、QT、QTc间期延长与T2DM患者发生颈动脉粥样硬化形成的关系。结果:CAS组患者的PR、QT、QTc时间均长于对照组患者,差异具有统计学意义(均P<0.05);CAS组患者的糖尿病病程长于对照组患者,CAS组患者中合并冠心病的占比高于对照组,差异具有统计学意义(均P<0.05);CAS组患者的血清甘油三酯(TG)、总胆固醇(TC)、高敏感度C-反应蛋白(hs-CRP)、丙氨酸氨基转移酶(ALT)水平均高于对照组患者,差异具有统计学意义(均P<0.05)。PR延长(OR=1.833)、QT延长(OR=1.718)、QTc延长(OR=1.487)、TG增高(OR=1.833)、hs-CRP增高(OR=2.081)、糖尿病病程延长(OR=2.036)是T2DM患者发生颈动脉粥样硬化的独立危险因素(均P<0.05)。结论:T2DM患者心电图PR、QT、QTc间期延长与发生颈动脉粥样硬化密切相关,可以作为早期监测患者颈动脉粥样硬化病变的筛选指标。Objective:To investigate the relationship between prolongation of ECG pulse rate(PR),QT,QTc interval and carotid atherosclerosis in type 2 diabetes mellitus(T2DM)patients.Methods:A case-control study was used to select 97 patients diagnosed with T2DM with carotid atherosclerosis(CAS)as the CAS group,and 95 patients diagnosed with T2DM without carotid atherosclerosis as the control group.Ecg PR,QT,QTc interval measurements,blood glucose and lipid levels were compared between the two groups.Multifactor analysis was used to investigate the relationship between prolonged PR,QT,QTc interval and carotid atherosclerosis in T2DM patients.Results:The duration of PR,QT and QTc in CAS group was longer than that in control group,and the difference was statistically significant(all P<0.05).The course of diabetes in CAS group was longer than that in control group,and the proportion of patients with coronary heart disease in CAS group was higher than that in control group,the difference was statistically significant(all P<0.05).The levels of serum triglyceride(TG),total cholesterol(TC),high-sensitivity C-reactive protein(hs-CRP)and alanine aminotransferase(ALT)in CAS group were higher than those in control group,and the differences were statistically significant(all P<0.05).Prolonged PR(OR=1.833),prolonged QT(OR=1.718),prolonged QTc(OR=1.487),increased TG(OR=1.833),increased hs-CRP(OR=2.081)and prolonged diabetes course(OR=2.036)were independent risk factors for carotid atherosclerosis in T2DM patients(all P<0.05).Conclusion:Through analysis,the prolongation of PR,QT,QTc intervals in the electrocardiogram of T2DM patients is closely related to the occurrence of carotid atherosclerosis,which can be used as a screening indicator for early monitoring of carotid atherosclerosis in patien.

关 键 词：心电图 PR间期 QT间期 QTC间期 2型糖尿病 颈动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]