血清单核细胞趋化蛋白1、高级氧化蛋白产物、尿微量白蛋白/肌酐比值与慢性肾衰竭患者血液透析治疗预后的相关性  

Correlation between serum MCP-1,AOPP,UACr and prognosis of patientswith chronic renal failure after hemodialysis treatment

作　　者：张解 马聪 孙婷婷 张雪 ZHANG Jie;MA Cong;SUN Tingting;ZHANG Xue(Blood Purification Center,Qingdao Jiaozhou Central Hospital,Qingdao 266300,China)

机构地区：[1]青岛市胶州中心医院血液净化中心,山东青岛266300 [2]青岛市胶州中心医院肾病风湿免疫科,山东青岛266300

出　　处：《陕西医学杂志》2025年第1期76-79,92,共5页Shaanxi Medical Journal

基　　金：山东省卫生健康委员会科研项目(2021KY01332)。

摘　　要：目的:探讨血清单核细胞趋化蛋白1(MCP-1)、高级氧化蛋白产物(AOPP)、尿微量白蛋白/肌酐比值(UACr)与慢性肾衰竭(CRF)患者血液透析治疗预后的关系。方法:选择116例经血液透析治疗的CRF患者为研究对象,以预后情况作为分组标准,即预后良好组和预后不良组,分别检测两组血清MCP-1、AOPP、尿UACr水平,分析其与CRF血液透析治疗预后的关系,受试者工作特征曲线(ROC)分析三者对预后的预测价值。结果:116例CRF血液透析治疗患者中预后不良42例(36.21%),预后良好74例(63.79%)。不同预后患者在年龄、合并症和血白蛋白(ALB)、MCP-1、AOPP、UACr水平上比较,差异有统计学意义(均P<0.05)。血清MCP-1、AOPP、UACr水平与CRF血液透析预后不良呈正相关(均P<0.05)。MCP-1、AOPP、UACr对血液透析治疗预后预测的曲线下面积(AUC)为0.875(95%CI:0.718~3.921),灵敏度87.50%,特异度90.79%(均P<0.05)。结论:CRF血液透析治疗预后不良患者血清MCP-1、AOPP水平和UACr值升高,三者与血液透析治疗预后关系密切。Objective:To investigate the relationship between serum monocyte chemotactic protein 1(MCP-1),advanced oxidized protein product(AOPP),urinary microalbumin/creatinine ratio(UACr)and the prognosis of patients with chronic renal failure(CRF)after hemodialysis treatment.Methods:A total of 116 patients with CRF undergoing hemodialysis were selected as the study objects,and the prognosis was used as the grouping criterion,that is,the good prognosis group and the poor prognosis group.Serum MCP-1,AOPP and urine UACr levels of the two groups were measured respectively,and the relationship between them and the prognosis of CRF hemodialysis treatment was analyzed.Receiver operating characteristic curve(ROC)was used to analyze the prognostic value of the three factors.Results:Among 116 patients treated with CRF hemodialysis,42 cases(36.21%)had poor prognosis and 74 cases(63.79%)had good prognosis.There were significant differences in age,comorbidities,ALB,MCP-1,AOPP and UACr among patients with different prognosis(all P<0.05).Serum MCP-1,AOPP and UACr levels were positively correlated with poor prognosis of CRF hemodialysis(all P<0.05).The area under the curve(AUC)of MCP-1,AOPP and UACr for prognosis of hemodialysis treatment was 0.875(95%CI:0.718~3.921),the sensitivity was 87.50%,and the specificity was 90.79%(all P<0.05).Conclusion:The serum levels of MCP-1,AOPP and UACr are increased in patients with poor prognosis after hemodialysis treatment of CRF,which are closely related to the prognosis.

关 键 词：单核细胞趋化蛋白1 高级氧化蛋白产物 尿微量白蛋白/肌酐比值 慢性肾衰竭 血液透析 预后 

分 类 号：R692.5[医药卫生—泌尿科学]