血清可溶性生长刺激表达基因2蛋白、胱抑素C、C反应蛋白与冠状动脉病变严重程度的相关性及预后影响因素分析  

Correlation between serum sST2,CysC,CRP and severity ofcoronary artery disease and prognostic factors

作　　者：冷俊 郁淼 秦兵 张莉 LENG Jun;YU Miao;QIN Bing;ZHANG Li(Department of Clinical Laboratory,Chongming Hospital,Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai 202150,China)

机构地区：[1]上海健康医学院附属崇明医院检验科,上海202150

出　　处：《陕西医学杂志》2025年第1期114-117,122,共5页Shaanxi Medical Journal

基　　金：科技部国家重点研发计划课题(2019YFF0216502)。

摘　　要：目的:探究血清可溶性生长刺激表达基因2蛋白(sST2)、胱抑素C(Cys C)、C反应蛋白(CRP)与冠状动脉病变严重程度的相关性并分析预后的影响因素。方法:选取170例冠状动脉病变患者为观察组,以冠状动脉病变严重程度分为轻度狭窄组(53例)、中度狭窄组(62例)、重度狭窄组(55例),并选同期100例健康体检者为对照组。比较不同组别患者血清sST2、CysC、CRP水平差异,Pearson相关性分析其与冠状动脉病变严重程度的关系。对所有患者进行6个月随访,预后良好(118例)、预后不良(52例),以多元Logistic回归分析影响预后的危险因素。结果:观察组血清sST2、CysC、CRP水平较对照组升高(均P<0.05)。重度狭窄组患者血清sST2、CysC、CRP水平高于轻度、中度狭窄组,中度狭窄组高于轻度狭窄组(均P<0.05)。Pearson相关性分析显示,冠状动脉病变严重程度与血清sST2(r=0.727)、CysC(r=0.644)、CRP(r=0.889)均表现为显著正相关(均P<0.05)。多元Logistic回归分析显示,高血压史、糖尿病史、高血脂症、病变血管、经皮冠状动脉介入术使用支架类型、sST2与CysC均为影响预后的独立危险因素(均P<0.05)。结论:冠状动脉病变程度越严重,患者血清sST2、CysC、CRP水平越高,且高血压史、糖尿病史、高血脂症、病变血管、经皮冠状动脉介入术使用支架类型、sST2与CysC均是影响患者预后的独立危险因素。Objective:To investigate the correlation between serum soluble growth STimulation expressed gene2(sST2),Cystatin C(Cys C)and C-reactive protein(CRP)and the severity of coronary artery disease,and to analyze the influencing factors of prognosis.Methods:A total of 170 patients with coronary artery disease were selected as the observation group,and divided into mild stenosis group(53 cases),moderate stenosis group(62 cases)and severe stenosis group(55 cases)according to the severity of coronary artery disease,and 100 healthy subjects were selected as the control group.The serum sST2,CysC and CRP levels in different groups were compared,and Pearson correlation analysis was conducted to analyze the relationship between sST2,CYSC and CRP levels and the severity of coronary artery disease.All patients were followed up for 6 months,and the prognosis was good(118 cases)and poor(52 cases).Multiple Logistic regression was used to analyze the risk factors affecting the prognosis.Results:The levels of sST2,CysC and CRP in the observation group were higher than those in the control group(all P<0.05).The levels of sST2,CysC and CRP in patients with severe stenosis were higher than those in mild and moderate stenosis groups,and those in moderate stenosis group were higher than those in mild stenosis group(all P<0.05).Pearson correlation analysis showed that the severity of coronary artery disease was significantly positively correlated with serum sST2(r=0.727),CysC(r=0.644)and CRP(r=0.889)(all P<0.05).Multiple Logistic regression analysis showed that history of hypertension,history of diabetes,hyperlipidemia,diseased vessels,stent type used in percutaneous coronary intervention,sST2 and CysC were independent risk factors for prognosis(all P<0.05).Conclusion:The more severe the degree of coronary artery disease,the higher the levels of serum sST2,CysC and CRP.Besides,history of hypertension,history of diabetes,hyperlipidemia,diseased vessels,type of stent used in percutaneous coronary intervention,sST2 and CysC are all independen

关 键 词：可溶性生长刺激表达基因2蛋白 胱抑素C C反应蛋白 冠状动脉病变 相关性 预后 影响因素 

分 类 号：R541.4[医药卫生—心血管疾病]