丹益活血汤加减对产科抗磷脂综合征相关复发性流产患者血清Tim-3、Gal-9、RAGE水平的影响  

Effect of modified Danyi Huoxue decoction on serum Tim-3,Gal-9 and RAGE in patientswith recurrent spontaneous abortion associated with obstetric antiphospholipid syndrome

作　　者：钱雅婷 周雪[1] 朱轶庆 QIAN Yating;ZHOU Xue;ZHU Yiqing(Department of Obstetrics and Gynecology,Nanjing Maternal and Child Health Hospital,Nanjing 210000,China)

机构地区：[1]南京市妇幼保健院产科,江苏南京210000

出　　处：《陕西中医》2025年第1期38-41,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82001546)。

摘　　要：目的:探讨丹益活血汤对产科抗磷脂综合征相关复发性流产(OAPS-RSA)患者血清黏蛋白域分子3(Tim-3)、半乳糖凝集素9(Gal-9)、晚期糖基化终末产物受体(RAGE)水平的影响。方法:选取128例OAPS-RSA患者,随机分为两组,对照组给予小剂量阿司匹林(LDA)联合低分子量肝素(LMWH)治疗,试验组加服丹益活血汤治疗,每组64例。比较两组疗效、治疗前后的子宫内膜容受性(ER)、血栓前状态(PTS)、血清Tim-3、Gal-9、RAGE水平及妊娠结局。结果:试验组总有效率更高(90.63%与76.56%)(P<0.05)。治疗后,与对照组比较,试验组EMT、Tim-3、Gal-9、RAGE均显著升高(P<0.05),PI、RI、FDP、D-D均显著降低(P<0.05)。试验组活产率高于对照组(P<0.05)。结论:丹益活血汤能够提升OAPS-RSA患者疗效,改善ER和PTS,升高血清Tim-3、Gal-9、RAGE水平,改善妊娠结局。Objective:To investigate the effects of modified Danyi Huoxue decoction on serum T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3),galactin-9(Gal-9)and receptor of advanced glycation endproducts(RAGE)in patients with obstetric antiphospholipid syndrome-related recurrent spontaneous abortion(OAPS-RSA).Methods:128 cases OAPS-RSA patients were randomly divided into 2 groups:the control group was treated with low-dose aspirin(LDA)combined with low molecular weight heparin(LMWH),and the observation group was treated with modified Danyi Huoxue decoction,with 64 cases in each group.The therapeutic effect,endometrial receptivity(ER),prethrombotic state(PTS),serum Tim-3,Gal-9,RAGE of 2 groups before and after treatment were compared,and the pregnancy outcome was followed up.Results:The total effective rate of the experimental group was higher(90.63%vs 76.56%)(P<0.05).After treatment,compared with the control group,the endometrial thickness(EMT),Tim-3,Gal-9 and RAGE in the experimental group had significantly increased,while pulse index(PI),resistance index(RI),serum fibrin degradation products(FDP)and D-dimer(D-D)had significantly decreased in the experimental group(P<0.05).Compared with the control group,the live birth rate had increased in the experimental group(P<0.05).Conclusion:The modified Danyi Huoxue decoction can improve the efficacy of OAPS-RSA patients,improve ER and PTS,increase serum levels of Tim-3,Gal-9 and RAGE,and improve pregnancy outcomes.

关 键 词：子宫内膜容受性 复发性流产 丹益活血汤 产科抗磷脂综合征 黏蛋白域分子3 半乳糖凝集素9 

分 类 号：R714.21[医药卫生—妇产科学]