健脾止动汤联合揿针治疗儿童多发性抽动症疗效及对患儿神经递质的影响  

The effect of Jianpi Zhidong decoction combined with thumb-tack needle on the treatment of children with tourette syndrome

作　　者：胡利军 张雯 王倩 崔霞 王素梅[2] 于文静 HU Lijun;ZHANG Wen;WANG Qian;CUI Xia;WANG Sumei;YU Wenjing(Department of Pediatrics,Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学第三附属医院儿科,北京100029 [2]北京中医药大学东方医院儿科,北京100078

出　　处：《陕西中医》2025年第1期118-121,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82305317);第七批全国老中医药专家学术经验继承项目[国中医药人教函(2022)76号];北京中医药大学青年教师项目(2018-JYBZZ-JS174)。

摘　　要：目的:探讨健脾止动汤联合揿针治疗儿童多发性抽动症的效果及对神经递质的影响。方法:选择96例多发性抽动症患儿为研究对象,随机分为观察组与对照组,各48例。观察组应用健脾止动汤联合揿针进行治疗,对照组患儿接受口服氟哌啶醇片治疗。观察治疗前后耶鲁综合抽动严重程度量表(YGTSS)评分、血清神经递质[多巴胺(DA)、去甲肾上腺素(NE)以及谷氨酸(GLU)、γ-氨基丁酸(GABA)]水平的变化以及临床疗效。结果:治疗后YGTSS量表评分显示两组患儿的运动抽动和发声抽动评分都明显下降,并且观察组的评分下降较对照组更为显著(P<0.05)。两组患儿血清中多巴胺(DA)、去甲肾上腺素(NE)和葡萄糖(GLU)水平均显著降低,而γ-氨基丁酸(GABA)水平则显著升高,且观察组的变化更为明显(P<0.05)。观察组的总有效率95.83%,高于对照组的83.33%,(P<0.05)。结论:健脾止动汤联合揿针治疗儿童多发性抽动症可以有效改善患儿临床症状,调节神经递质失衡,进而提高临床疗效。Objective:To explore the effect of Jianpi Zhidong decoction combined with thumb-tack needle in the treatment of children with tourette syndrome and its impact on neurotransmitters.Methods:96 children with tourette syndrome were included as the study subjects,and then divided into the observation group and control group in a random manner,each of 48 cases.The observation group was treated with Jianpi Zhidong decoction in combination with thumb-tack needle,while the control group received oral haloperidol tablets.The changes in YGTSS scores,serum neurotransmitter levels[dopamine(DA),norepinephrine(NE),glutamate(GLU),gamma aminobutyric acid(GABA)]before and after treatment was compared,as well as clinical efficacy.Results:After treatment,both groups of children showed a significant decrease in their YGTSS scores for motor and vocal tics,with the observation group showing a more pronounced decrease(P<0.05).After treatment,serum levels of DA,NE,and GLU were significantly reduced in both groups of children,while GABA was increased significantly,but the changes were more significant in the observation group,and the differences were all significant(P<0.05).The total effective rate of treatment was 95.83%in the observation group,which was higher than the 83.33%observed in the control group(P<0.05).Conclusion:Jianpi Zhidong decoction in combination with thumb-tack needle can effectively improve the clinical symptoms of children with tourette syndrome,regulate neurotransmitter imbalances,and thereby enhance clinical efficacy.

关 键 词：多发性抽动症 健脾止动汤 揿针 儿童 神经递质 

分 类 号：R729[医药卫生—儿科]