超高分辨率超声测量兔颈动脉粥样硬化斑块内新生血管的应用价值  

Application of Rabbit Carotid Atherosclerotic Plaque Neovascularization using Ultrasound Localization Microscopy

作　　者：任俊奕 白文坤[1] 郑元义 REN Junyi;BAI Wenkun;ZHENG Yuanyi(Department of Ultrasound,Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China)

机构地区：[1]上海交通大学医学院附属第六人民医院超声科,200233

出　　处：《医学研究杂志》2024年第11期35-39,共5页Journal of Medical Research

基　　金：国家自然科学基金资助项目(82030050)。

摘　　要：目的 探讨超高分辨率超声(ultrasound localization microscopy, ULM)技术测量兔颈动脉粥样硬化斑块内新生血管参数与病理结果的相关性。方法 使用球囊损伤联合高脂饮食建立兔颈动脉粥样硬化易损斑块模型,利用SRUS技术测量斑块内新生血管,定量新生血管密度、直径、扭曲度、速度参数,并与病理学结果进行比较,评估SRUS技术检测及测量斑块内新生血管参数方面的可靠性。结果 SRUS技术可以对兔颈动脉粥样硬化易损斑块内的新生血管进行超高分辨率成像,同时可以准确测量斑块内新生血管的密度。与病理学诊断的相关性较好(r=0.915,P<0.05)。结论 SRUS技术检测兔颈动脉粥样硬化斑块内新生血管具有一定的可靠性。Objective To investigate the correlation between intraplaque neovascularization(IPN)parameters using ultrasound localization microscopy(ULM)and pathological results.Methods Atherosclerosis of the carotid artery in rabbit was induced using balloon catheter damage and a high-cholesterol diet.ULM technology was used to measure the IPN,and the parameters of neovascularization density,diameter,distortion and velocity were quantified,and compared with pathological results,to evaluate the reliability of ULM technique in detecting and measuring the parameters of IPN.Results ULM technology can perform ultra-high resolution imaging of the IPN in rabbit carotid atherosclerotic plaques,and can accurately measured the density of IPN.The correlation with pathological diagnosis was good(r=0.915,P<0.05).Conclusion ULM technique has a certain reliability in detecting the IPN in rabbit carotid atherosclerotic plaque.

关 键 词：斑块内新生血管 超高分辨率超声 人工智能 

分 类 号：R5[医药卫生—内科学]