非特殊型浸润性乳腺癌超声造影边缘带增强特征及定量参数与Ki-67的相关性分析  

Correlation Analysis of Marginal Zone Enhancement Features and Quantitative Parameters of Contrast-enhanced Ultrasound with Ki-67 in Invasive Breast Carcinoma of No Specific Type

作　　者：王婧婕 贾春梅[1] 陈耀东 WANG Jingjie;JIA Chunmei;CHEN Yaodong(The First Hospital of Shanxi Medical University,Shanxi 030001,China)

机构地区：[1]山西医科大学第一医院超声科,太原030001

出　　处：《医学研究杂志》2024年第11期73-76,63,共5页Journal of Medical Research

基　　金：山西省重点研发计划项目(201803D31097)。

摘　　要：目的 探讨非特殊型浸润性乳腺癌(invasive breast carcinoma of no specific type, IBC-NST)边缘带二维超声特征、超声造影增强特征及定量参数与Ki-67的相关性。方法 收集2019年10月~2023年10月在山西医科大学第一医院经手术病理及免疫组化证实的IBC-NST患者84例(84个单侧单发病灶),年龄25~78岁,所有患者术前均未进行放化疗,且均行二维超声、超声造影检查。根据Ki-67表达程度将其分为高表达组和低表达组,分析对比两组病灶边缘带二维超声特征、超声造影增强特征及定量参数,分析定量参数与Ki-67的相关性。结果 Ki-67高表达组IBC-NST患者病灶边缘带边界模糊比例高于Ki-67低表达组,差异均有统计学意义(P<0.05)。Ki-67高表达组IBC-NST患者病灶边缘带增强特征、边缘放射状增强、造影后范围扩大比例均高于Ki-67低表达组,差异均有统计学意义(P<0.05)。Ki-67高表达组IBC-NST患者病灶边缘带超声造影定量参数峰值强度(peak intensity, PI)、曲线下面积(area under the curve, AUC)均高于Ki-67低表达组,差异均有统计学意义(P<0.05)。IBC-NST边缘带定量参数PI、AUC与Ki-67表达呈正相关,差异均有统计学意义(P<0.05)。结论 IBC-NST患者病灶边缘带边界模糊、边缘放射状增强、造影后范围扩大、定量参数PI、AUC升高可提示Ki-67高表达,为临床个体化精准治疗提供了一定的影像学指导。Objective To explore the correlation between marginal zone two-dimensional ultrasound features,enhancement features and quantitative parameters of contrast-enhanced ultrasound and Ki-67 in the invasive breast carcinoma of no specific type(IBC-NST).Methods From October 2019 to October 2023,84 patients with IBC-NST(84 unilateral lesions),aged 25 to 78 years,confirmed by surgical pathology and immunohistochemistry were collected from the First Hospital of Shanxi Medical University.All patients had not received preoperative chemoradiotherapy,and underwented two-dimensional ultrasound and contrast-enhanced ultrasound examination.They were divided into high expression group and low expression group according to the expression degree of Ki-67.The two-dimensional ultrasound features and contrast-enhanced ultrasound features and quantitative parameters of two groups were analyzed and compared,and their correlation between the quantitative parameters and Ki-67 was analyzed.Results The proportion of margin indistinct of IBC-NST lesion in Ki-67 high expression group was higher than that in Ki-67 low expression group,and the differences were statistically significant(P<0.05).The proportion of adial enhancemen and the range enlargement after angiography of IBC-NST lesion in Ki-67 high expression group was higher than those in Ki-67 low expression group,and the differences were statistically significance(P<0.05).The quantitative parameters peak intensity(PI),area under the curve(AUC)of IBC-NST lesion in Ki-67 high expression group were higher than those in Ki-67 low expression group,and the differences were statistically significant(P<0.05).IBC-NST marginal zone quantitative parameters PI,AUC were positively correlated with Ki-67 expression,and the differences were statistically significant(P<0.05).Conclusion In patients with IBC-NST,the marginal zone of the lesion is margin indistinct,the radial enhancement,the srange enlargement after angiography,and the quantitative parameters PI,AUC are increased,indicating the high express

关 键 词：非特殊型浸润性乳腺癌 超声造影 边缘带 KI-67 

分 类 号：R445.1[医药卫生—影像医学与核医学]