不同剂型药物鼻饲给药的研究进展  

Progress in research on nasogastric administration of different dosage forms of drugs

作　　者：杨丽萍 吴汀溪 王海玲 赵志刚[1] Liping YANG;Tingxi WU;Hailing WANG;Zhigang ZHAO(Department of Pharmacy,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院药学部,北京100070

出　　处：《临床药物治疗杂志》2024年第10期7-11,共5页Clinical Medication Journal

基　　金：国家卫生健康委药具管理中心立项课题(国卫药管ZDC2022001);中国药品监督管理研究会研究课题(2023-Y-Y-018)。

摘　　要：鼻饲给药作为危重症患者的重要给药途径,在实际操作中面临诸多挑战。尤其当涉及特殊剂型药物与包衣药物的鼻饲处理时,任何不当操作都可能导致药物疗效减弱、不良反应风险增加。鉴于此,为确保鼻饲给药的安全性与有效性,要求在给药前进行严格的评估。然而,我国目前在鼻饲给药领域缺乏系统全面的实践指南与操作规范,且无专为经鼻饲途径设计的药物剂型,给临床操作带来了极大困扰。针对这一现状,本文通过检索相关文献,梳理我国基本药物目录与医保目录,从药物剂型、制备工艺等方面进行探讨与总结,筛选出适宜鼻饲的药物,旨在为临床提供科学合理的用药建议。As a crucial drug delivery method for patients in critical condition,nasogastric administration presents numerous practical difficulties.Any incorrect handling of special dosage forms and coated medications,particularly when administered nasally,may reduce their effectiveness and raise the possibility of negative side effects.Because of this,rigorous evaluation is necessary prior to administration in order to guarantee the safety and effectiveness of nasogastric administration.However,there is a lack of systematic and comprehensive practice guidelines and operation standards in the field of nasal administration in China,and there is no drug dosage form specifically designed for the nasal route,which brings great trouble to clinical operations.In order to address this situation,relevant literature were searched and China's basic drug catalogue and medical insurance catalogue were referred in this article.It also discussed and summarized aspects like drug formulation and manufacturing processes to screen appropriate medications for nasogastric administration,aiming to provide scientific and rational medication recommendations for clinical use.

关 键 词：鼻饲 用药分析 合理用药 

分 类 号：R943[医药卫生—药剂学]