基于专利的信使核糖核酸递送系统领域主题挖掘及技术演进分析  

Patent-based topic mining and technology evolution analysis in the field of messenger ribonucleic acid delivery systems

作　　者：张敏 吴桐 魏东林 张晴 赵迎迎 袁红梅[1] ZHANG Min;WU Tong;WEI Dong-lin;ZHANG Qing;ZHAO Ying-ying;YUAN Hong-mei(Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学,沈阳110016

出　　处：《中国新药杂志》2024年第23期2426-2432,共7页Chinese Journal of New Drugs

基　　金：上海药品审评核查中心科研项目(2222430097)。

摘　　要：信使核糖核酸(messenger ribonucleic acid,mRNA)递送系统是研制mRNA药物的关键技术,也是目前国内外开发mRNA药物的企业关注的重点。本研究以Incopat数据库为数据来源,运用隐含狄利克雷分配(latent dirichlet allocation,LDA)和主路径-衍生路径分析对mRNA递送系统领域的技术重点、技术轨迹进行系统分析。LDA的结果明确了该领域的重点递送载体,如脂质纳米粒(lipid nanoparticles,LNP)和mRNA递送技术的应用现状;主路径-衍生路径的结果将mRNA递送系统的技术趋势分为2个阶段,前期以mRNA递送载体的研发及结构优化为主,后期以mRNA递送系统的临床应用为重点;除此之外,Moderna公司和Translate Bio公司为主路径-衍生路径上最具优势的2个专利权人。本研究所得结果有助于为企业制定更好的mRNA递送策略和mRNA药物研发管线提供有益参考。Messenger ribonucleic acid(mRNA)delivery system is a key technology in developing the mRNA drugs,and it is also a focus of attention for domestic and foreign companies developing mRNA drugs at present.In this study,the Incopat database was applied as a data source to systematically analyze the technological focus and technological trajectory in the field of mRNA delivery systems using the methods of implied Dirichlet allocation(LDA)and the main path-derivative path analyses.The results of LDA clarify the key delivery vectors in this field,such as lipid nanoparticles(LNP)and the current status of the application of mRNA delivery technology.The results of the main path-derivative path indicated that the technological trend of mRNA delivery systems was divided into two phases,with the first stage mainly focusing on the development and structure optimization of mRNA delivery vectors,and the second one focusing on the clinical application of mRNA delivery systems.In addition,Moderna and Translate Bio are two of the most advantageous patentees in the main path-derivative path.The results of this study are helpful for enterprises to develop better mRNA delivery strategies and mRNA drug development pipeline.

关 键 词：mRNA递送系统 隐含狄利克雷分配主题模型 主路径分析 衍生路径分析 专利分析 

分 类 号：R95[医药卫生—药学]