酶促多肽自组装应用于肿瘤成像研究进展  

Research progress of enzyme-responsive peptide self-assembly for tumor imaging

作　　者：吴羽婧 周鹏 吴昊[2] 谢敏浩 WU Yu-jing;ZHOU Peng;WU Hao;XIE Min-hao(Department of Radiopharmaceuticals,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;NHC Key Laboratory of Nuclear Medicine,Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China)

机构地区：[1]南京医科大学药学院核药学系,南京211166 [2]国家卫生健康委员会核医学重点实验室/江苏省分子核医学重点实验室/江苏省原子医学研究所,无锡214063

出　　处：《中国新药杂志》2024年第23期2482-2488,共7页Chinese Journal of New Drugs

基　　金：江苏省中医药科技发展计划资助项目(YB2020103)。

摘　　要：肿瘤成像在非侵入性癌症诊断和治疗监测中具有关键作用,可提供直观的肿瘤图像信息,有助于实现癌症的早期发现、定位和分期,对于提高癌症患者的生存率和改善生活质量至关重要。酶促多肽自组装策略通过在原位形成探针分子的纳米结构,促使成像探针在肿瘤的聚集和滞留,从而提高肿瘤成像的准确性和灵敏度。本综述总结了酶促多肽自组装探针的设计原理和在肿瘤成像中的最新进展,涵盖了荧光成像(fluorescence imaging,FI)、磁共振成像(magnetic resonance imaging,MRI)和正电子断层扫描(positron emission tomography,PET)成像等领域,并对拓展该策略契合的肿瘤靶点的方法进行了讨论。Tumor imaging plays a crucial role in the non-invasive diagnosis and monitoring of cancer,providing visual information essential for early detection,localization,and staging.It is pivotal for improving the survival rates and enhancing the life quality for cancer patients.The enzyme-responsive peptide self-assembly strategy,by inducing the in-situ formation of probe molecules into nanostructures,facilitates the aggregation and retention of imaging probes in tumors,thereby enhancing the accuracy and sensitivity of tumor imaging.This review comprehensively outlines the design principles and recent advancements of enzyme-responsive peptide self-assembling probes of tumor imaging.Encompassing multiple imaging modalities,including fluorescence imaging(FI),magnetic resonance imaging(MRI),and positron emission tomography(PET),the review also discusses the approaches for expanding the applicability of this strategy to diverse tumor targets.

关 键 词：酶促多肽自组装 肿瘤成像 荧光成像 磁共振成像 正电子发射断层扫描 

分 类 号：R95[医药卫生—药学]