益肾促排卵汤联合来曲唑治疗对PCOS不孕症患者内分泌水平、卵巢功能及血清Ghrelin、AMH、NF-κB的影响  

Effect of Yishen Ovulation-Promoting Decoction Combined with Letrozole on Endocrine Level,Ovarian Function and Serum Ghrelin,AMH and NF-κB in Patients with PCOS Infertility

作　　者：李静静 李若涵 马函琳 李志芳 钱麟 LI Jing-jing;LI Ruo-han;MA Han-lin;LI Zhi-fang;QIAN Lin(Shuguang Clinical Medical College of Shanghai University of Traditional Chinese Medicine,Shanghai,200120,China;Department of Gynaecology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200120,China;Department of Traditional Chinese Medicine,Shanghai Pudong New Area Gongli Hospital,Shanghai,200135,China)

机构地区：[1]上海中医药大学曙光临床医学院,上海200120 [2]上海中医药大学附属曙光医院妇科,上海200120 [3]上海市浦东新区公利医院中医科,上海200135

出　　处：《现代生物医学进展》2024年第22期4227-4229,共3页Progress in Modern Biomedicine

基　　金：上海市卫生和计划生育委员上海市进一步加快中医药事业发展三年行动计划[ZY(2018-2020)-RCPY-3012]。

摘　　要：目的:探讨多囊卵巢综合征(PCOS)不孕症采用来曲唑、益肾促排卵汤联合治疗后,对患者卵巢功能、内分泌水平、血清生长激素释放肽(Ghrelin)、抗苗勒管激素(AMH)、核转录因子κB(NF-κB)的影响。方法:将我院PCOS不孕症患者(132例)随机分为对照组(66例,来曲唑治疗)和试验组(66例,来曲唑、益肾促排卵汤联合治疗)。对比两组内分泌指标、卵巢功能指标、血清Ghrelin、AMH、NF-κB水平、排卵及妊娠情况。结果:与对照组治疗后相比,试验组基础促黄体生成素(LH)、搏动指数、阻力指数、NF-κB、AMH更低,黄体中期雌二醇(E_(2))、黄体中期孕酮(P)、子宫内膜厚度、Ghrelin更高(P<0.05)。随访六个月后,试验组的排卵率、妊娠率高于对照组(P<0.05)。结论:PCOS不孕症采用来曲唑、益肾促排卵汤联合治疗后,可有效改善患者内分泌水平、卵巢功能及血清Ghrelin、AMH、NF-κB水平,提高妊娠率和排卵率。Objective:To investigate the effects of letrozole combined with yishen ovulation-promoting decoction on ovarian function,endocrine level,serum growth hormone releasing peptide(Ghrelin),anti-Mullerian hormone(AMH)and nuclear transcription factor-κB(NF-κB)in patients with polycystic ovary syndrome(PCOS)infertility.Methods:Patients with PCOS infertility(132 cases)in our hospital were randomly divided into control group(66 cases,letrozole treatment)and experimental group(66 cases,letrozole,yishen ovulation-promoting decoction combined treatment).Endocrine indexes,ovarian function indexes,serum Ghrelin,AMH,NF-κB levels,ovulation and pregnancy were compared between two groups.Results:Compared with control group after treatment,basic luteinizing hormone(LH),pulsatility index,resistance index,NF-κB,AMH in experimental group were lower,and mid-luteal estradiol(E_(2)),mid-luteal progesterone(P),endometrial thickness,Ghrelin were higher(P<0.05).Six months after follow-up,the ovulation rate and pregnancy rate in experimental group were higher than those in control group(P<0.05).Conclusion:Letrozole combined with yishen ovulation-promoting decoction in the treatment of PCOS infertility patients,which can effectively improve the endocrine level,ovarian function,serum Ghrelin,AMH and NF-κB levels,and improve the pregnancy rate and ovulation rate.

关 键 词：益肾促排卵汤 来曲唑 多囊卵巢综合征不孕症 内分泌水平 卵巢功能 Ghrelin AMH NF-ΚB 

分 类 号：R711[医药卫生—妇产科学]