加味芍甘附子汤联合温和灸对寒湿痹阻型活动期类风湿关节炎患者免疫功能和血清IL-1β、IL-6、IL-18的影响  

Effects of Jiawei Shaogan Fuzi Decoction Combined with Mild Moxibustion on Immune Function and Serum IL-1β,IL-6 and IL-18 in Patients with Active Rheumatoid Arthritis of Cold-Dampness Obstruction Type

作　　者：刘亚伟 马俊福[2] 谷慧敏[2] 杨双庆 李玉洁 李锦锦 LIU Ya-wei;MA Jun-fu;GU Hui-min;YANG Shuang-qing;LI Yu-jie;LI Jin-jin(School of Orthopedics and Traumatology,Henan University of Chinese Medicine,Zhengzhou,Henan,450046,China;Department of Rheumatology,Henan Provincial Hospital of TCM,Zhengzhou,Henan,450002,China)

机构地区：[1]河南中医药大学骨伤学院,河南郑州450046 [2]河南省中医院风湿病科,河南郑州450002

出　　处：《现代生物医学进展》2024年第22期4247-4249,共3页Progress in Modern Biomedicine

基　　金：河南省中医药科学研究专项课题(2022ZY1062);国家自然科学基金青年项目(81804050);河南省中医药学科拔尖人才资助项目({豫卫中医[2021]15号})。

摘　　要：目的:观察加味芍甘附子汤、温和灸联合治疗寒湿痹阻型活动期类风湿关节炎(RA)患者,对免疫功能和血清白细胞介素(IL)-1β、IL-6、IL-18的影响。方法:选取142例活动期RA患者(寒湿痹阻型)按随机数字表法分为对照组(温和灸治疗,n=71)和b联合组(加味芍甘附子汤联合温和灸治疗,n=71)。对比两组疗效、实验室指标、免疫功能和血清炎症因子。结果:与对照组相比,联合组的临床总有效率明显升高(P<0.05)。与对照组治疗后相比,联合组的类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白G(Ig G)、免疫球蛋白G(Ig A)、免疫球蛋白M(Ig M)、IL-1β、IL-6、IL-18更低(P<0.05)。结论:加味芍甘附子汤联合温和灸治疗寒湿痹阻型活动期RA患者,可提高临床治疗效果,调节免疫功能和抑制血清IL-1β、IL-6、IL-18水平。Objective:To observe the combined treatment of jiawei shaogan fuzi decoction and mild moxibustion in patients with active rheumatoid arthritis(RA)of cold-dampness obstruction type,the effects on immune function and serum interleukin(IL)-1β,IL-6,IL-18.Methods:142 patients with active RA(cold-dampness obstruction type)were divided into control group(mild moxibustion treatment,n=71)and combine group(Jiawei Shaogan Fuzi Decoction combine with mild moxibustion treatment,n=71)according to the random number table method.The efficacy,laboratory indexes,immune function and serum inflammatory factors were compared between two groups.Results:Compared with control group,the total clinical effective rate in combine group was significantly higher(P<0.05).Compared with control group after treatment,rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),immunoglobulin G(IgG),immunoglobulin G(IgA),immunoglobulin M(IgM),IL-1β,IL-6 and IL-18 in combine group were lower(P<0.05).Conclusion:Jiawei shaogan fuzi decoction combined with mild moxibustion can improve clinical treatment effect,regulate immune function and inhibit serum IL-1β,IL-6 and IL-18 levels in patients with active RA of cold-dampness obstruction type.

关 键 词：加味芍甘附子汤 活动期 温和灸 寒湿痹阻型 免疫功能 IL-1β IL-6 IL-18 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]